BMP10
Bone morphogenetic protein 10
Also known as: BMP10_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95393
- Gene
- BMP10
- Ensembl
- ENSG00000163217
- Chromosome
- 2
- Canonical length
- 424 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]
Canonical amino-acid sequenceUniProt
424 residues, UniProt reviewed canonical sequence.
>O95393|BMP10
1 MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD FNTLLQSMKD
61 EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLFSQPVSF
121 NGLRKYPLLF NVSIPHHEEV IMAELRLYTL VQRDRMIYDG VDRKITIFEV LESKGDNEGE
181 RNMLVLVSGE IYGTNSEWET FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE
241 IDTSAQNKHN PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL
301 QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY ECRGVCNYPL
361 AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL YLDKGVVTYK FKYEGMAVSE
421 CGCRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BMP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 727 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 727 nTPM
- liver: 6.1 nTPM
- pancreas: 0.8 nTPM
- breast: 0.3 nTPM
- salivary gland: 0.3 nTPM
- cerebral cortex: 0.2 nTPM
Single-cell type
- hepatic stellate cells: 13 nCPM
- kupffer cells: 2 nCPM
- late spermatids: 1.5 nCPM
- early spermatids: 1.3 nCPM
- adipocytes: 0.9 nCPM
- b-cells: 0.3 nCPM
Immune cell
- T-reg: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.39
- gnomAD pLI
- 0.91
- gnomAD missense Z
- 1.02
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- activin receptor signaling pathway
- adult heart development
- atrial cardiac muscle tissue morphogenesis
- BMP signaling pathway
- cardiac muscle cell proliferation
- cell adhesion
- heart trabecula formation
- kidney development
- negative regulation of cardiac muscle hypertrophy
- negative regulation of cell growth
- negative regulation of cell migration
- negative regulation of endothelial cell migration
- positive regulation of cardiac muscle cell proliferation
- positive regulation of cardiac muscle hypertrophy
- positive regulation of cartilage development
- positive regulation of cell proliferation involved in heart morphogenesis
- positive regulation of DNA-templated transcription
- positive regulation of gene expression
- positive regulation of sarcomere organization
- positive regulation of SMAD protein signal transduction
- regulation of cardiac muscle contraction
- regulation of cardiac muscle hypertrophy in response to stress
- sarcomere organization
- ventricular cardiac muscle cell development
- ventricular cardiac muscle tissue morphogenesis
Molecular functions
- cytokine activity
- growth factor activity
- hormone activity
- receptor serine/threonine kinase binding
- telethonin binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BMP10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BMP10 as an antibody target. Whether an autoantibody or antibody against BMP10 could matter depends on whether native BMP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BMP10 is annotated as secreted, so native BMP10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label BMP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...