Seroatlas · Human Serome Atlas

BMP6

Bone morphogenetic protein 6

Also known as: BMP6_HUMAN, VGR, VGR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P22004
Gene
BMP6
Ensembl
ENSG00000153162
Chromosome
6
Canonical length
513 aa
Protein class
Predicted secreted proteins
Subcellular location
Mitochondria
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>P22004|BMP6
     1  MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP GRTEQPPPSP
    61  QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ QPQPPALRQQ EEQQQQQQLP
   121  RGEPPPGRLK SAPLFMLDLY NALSADNDED GASEGERQQS WPHEAASSSQ RRQPPPGAAH
   181  PLNRKSLLAP GSGSGGASPL TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF
   241  NLSQIPEGEV VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA
   301  SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD GPYDKQPFMV
   361  AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA SDYNSSELKT ACRKHELYVS
   421  FQDLGWQDWI IAPKGYAANY CDGECSFPLN AHMNATNHAI VQTLVHLMNP EYVPKPCCAP
   481  TKLNAISVLY FDDNSNVILK KYRNMVVRAC GCH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 19 nTPM
  • placenta: 17 nTPM
  • adipose tissue: 14 nTPM
  • kidney: 12 nTPM
  • breast: 11 nTPM
  • choroid plexus: 7.8 nTPM

Single-cell type

  • pituitary stem cells: 364 nCPM
  • plasma cells: 349 nCPM
  • platelets: 344 nCPM
  • oocytes: 170 nCPM
  • vascular endothelial cells: 164 nCPM
  • neutrophils: 156 nCPM

Immune cell

  • basophil: 1.1 nTPM
  • neutrophil: 0.6 nTPM
  • total PBMC: 0.5 nTPM
  • myeloid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • cerebral cortex: 9.9 nTPM
  • basal ganglia: 8.7 nTPM
  • thalamus: 8.7 nTPM
  • amygdala: 7.1 nTPM
  • medulla oblongata: 6.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BMP6.

Disease | AllUniProt

Conditions BMP6 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 134 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.76
gnomAD missense Z
-1.03
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BMP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMP6 as an antibody target. Whether an autoantibody or antibody against BMP6 could matter depends on whether native BMP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMP6 is annotated as secreted, so native BMP6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BMP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BMP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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