Seroatlas · Human Serome Atlas

LEFTY1

Left-right determination factor 1

Also known as: LEFTB, LEFTYB, LFTY1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75610
Gene: LEFTY1
Ensembl: ENSG00000243709
Chromosome: 1
Canonical length: 366 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>O75610|LEFTY1
     1  MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE LVIPTHVRAQ
    61  YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV FGMEQRLPPN SELVQAVLRL
   121  FQEPVPKAAL HRHGRLSPRS ARARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV
   181  TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL
   241  DLGDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP
   301  PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV
   361  PRRLQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LEFTY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

pancreas: 91 nTPM
colon: 65 nTPM
rectum: 30 nTPM
appendix: 7.4 nTPM
epididymis: 6.5 nTPM
ovary: 3.8 nTPM

Single-cell type

endometrial luminal cells: 414 nCPM
enteric stem cells: 384 nCPM
enteric transient amplifying cells: 190 nCPM
colonocytes: 183 nCPM
pancreatic duct cells: 179 nCPM
endometrial ciliated cells: 103 nCPM

Immune cell

basophil: 17 nTPM
total PBMC: 1.1 nTPM
NK-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 2.3 nTPM
basal ganglia: 2.1 nTPM
hippocampal formation: 2.1 nTPM
amygdala: 2 nTPM
hypothalamus: 1.6 nTPM
white matter: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LEFTY1 as an antibody target. Whether an autoantibody or antibody against LEFTY1 could matter depends on whether native LEFTY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LEFTY1 is annotated as secreted, so native LEFTY1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LEFTY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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