Seroatlas · Human Serome Atlas

INHBA

Inhibin beta A chain

Also known as: INHBA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08476
Gene
INHBA
Ensembl
ENSG00000122641
Chromosome
7
Canonical length
426 aa
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>P08476|INHBA
     1  MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS QPEMVEAVKK
    61  HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT
   121  SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK
   181  HPQGSLDTGE EAEEVGLKGE RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV
   241  RIACEQCQES GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS
   301  EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG
   361  TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV
   421  EECGCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INHBA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • gallbladder: 20 nTPM
  • blood vessel: 19 nTPM
  • endometrium: 16 nTPM
  • lung: 10 nTPM
  • placenta: 10 nTPM
  • bone marrow: 9.8 nTPM

Single-cell type

  • fibroblasts: 346 nCPM
  • syncytiotrophoblasts: 253 nCPM
  • leydig cells: 225 nCPM
  • neutrophil progenitors: 166 nCPM
  • pancreatic islet cells: 127 nCPM
  • vascular smooth muscle cells: 109 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • hippocampal formation: 18 nTPM
  • midbrain: 17 nTPM
  • cerebral cortex: 16 nTPM
  • spinal cord: 9.6 nTPM
  • medulla oblongata: 9.3 nTPM
  • white matter: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.98
gnomAD missense Z
2.5
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INHBA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INHBA as an antibody target. Whether an autoantibody or antibody against INHBA could matter depends on whether native INHBA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INHBA is annotated as secreted, so native INHBA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label INHBA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INHBA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...