Seroatlas · Human Serome Atlas

MPND

MPN domain-containing protein

Also known as: FLJ14981, MPND_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N594
Gene: MPND
Ensembl: ENSG00000008382
Chromosome: 19
Canonical length: 471 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli rim
Quaternary structure: Homotetramer

OverviewNCBI Gene

Predicted to enable metallopeptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in double-strand break repair. Predicted to be part of BRCA1-A complex and BRISC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q8N594|MPND
     1  MAAPEPLSPA GGAGEEAPEE DEDEAEAEDP ERPNAGAGGG RSGGGGSSVS GGGGGGGAGA
    61  GGCGGPGGAL TRRAVTLRVL LKDALLEPGA GVLSIYYLGK KFLGDLQPDG RIMWQETGQT
   121  FNSPSAWATH CKKLVNPAKK SGCGWASVKY KGQKLDKYKA TWLRLHQLHT PATAADESPA
   181  SEGEEEELLM EEEEEDVLAG VSAEDKSRRP LGKSPSEPAH PEATTPGKRV DSKIRVPVRY
   241  CMLGSRDLAR NPHTLVEVTS FAAINKFQPF NVAVSSNVLF LLDFHSHLTR SEVVGYLGGR
   301  WDVNSQMLTV LRAFPCRSRL GDAETAAAIE EEIYQSLFLR GLSLVGWYHS HPHSPALPSL
   361  QDIDAQMDYQ LRLQGSSNGF QPCLALLCSP YYSGNPGPES KISPFWVMPP PEMLLVEFYK
   421  GSPDLVRLQE PWSQEHTYLD KLKISLASRT PKDQSLCHVL EQVCGVLKQG S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPND can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

liver: 45 nTPM
cerebral cortex: 31 nTPM
duodenum: 29 nTPM
amygdala: 28 nTPM
colon: 24 nTPM
pancreas: 23 nTPM

Single-cell type

colonocytes: 71 nCPM
enterocytes: 50 nCPM
megakaryocytes: 50 nCPM
kupffer cells: 39 nCPM
enteric transient amplifying cells: 32 nCPM
goblet cells: 31 nCPM

Immune cell

basophil: 9.3 nTPM
intermediate monocyte: 3.8 nTPM
T-reg: 3.7 nTPM
classical monocyte: 3.1 nTPM
myeloid DC: 3 nTPM
plasmacytoid DC: 2.9 nTPM

Brain region

cerebellum: 38 nTPM
white matter: 34 nTPM
cerebral cortex: 34 nTPM
pons: 31 nTPM
amygdala: 29 nTPM
hippocampal formation: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPND as an antibody target. Whether an autoantibody or antibody against MPND could matter depends on whether native MPND is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPND is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPND as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...