Seroatlas · Human Serome Atlas

BRCC3

Lys-63-specific deubiquitinase BRCC36

Also known as: BRCC3_HUMAN, BRCC36, C6.1A, CXorf53

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46736
Gene
BRCC3
Ensembl
ENSG00000185515
Chromosome
X
Canonical length
316 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>P46736|BRCC3
     1  MAVQVVQAVQ AVHLESDAFL VCLNHALSTE KEEVMGLCIG ELNDDTRSDS KFAYTGTEMR
    61  TVAEKVDAVR IVHIHSVIIL RRSDKRKDRV EISPEQLSAA STEAERLAEL TGRPMRVVGW
   121  YHSHPHITVW PSHVDVRTQA MYQMMDQGFV GLIFSCFIED KNTKTGRVLY TCFQSIQAQK
   181  SSESLHGPRD FWSSSQHISI EGQKEEERYE RIEIPIHIVP HVTIGKVCLE SAVELPKILC
   241  QEEQDAYRRI HSLTHLDSVT KIHNGSVFTK NLCSQMSAVS GPLLQWLEDR LEQNQQHLQE
   301  LQQEKEELMQ ELSSLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRCC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 22 nTPM
  • colon: 21 nTPM
  • duodenum: 18 nTPM
  • epididymis: 18 nTPM
  • esophagus: 17 nTPM
  • salivary gland: 17 nTPM

Single-cell type

  • esophageal apical cells: 75 nCPM
  • esophageal suprabasal cells: 53 nCPM
  • prostatic glandular cells: 49 nCPM
  • tuft cells: 46 nCPM
  • thyrotrophs: 46 nCPM
  • epicardial cells: 46 nCPM

Immune cell

  • basophil: 37 nTPM
  • eosinophil: 34 nTPM
  • NK-cell: 28 nTPM
  • T-reg: 26 nTPM
  • non-classical monocyte: 24 nTPM
  • MAIT T-cell: 23 nTPM

Brain region

  • cerebellum: 20 nTPM
  • hypothalamus: 19 nTPM
  • midbrain: 18 nTPM
  • choroid plexus: 18 nTPM
  • pons: 18 nTPM
  • cerebral cortex: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0.01
gnomAD missense Z
2.67
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRCC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRCC3 as an antibody target. Whether an autoantibody or antibody against BRCC3 could matter depends on whether native BRCC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRCC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRCC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BRCC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...