Seroatlas · Human Serome Atlas

STAMBPL1

AMSH-like protease

Also known as: ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, FLJ31524, KIAA1373, STALP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FJ0
Gene: STAMBPL1
Ensembl: ENSG00000138134
Chromosome: 10
Canonical length: 436 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Enables K63-linked deubiquitinase activity. Involved in cellular response to L-leucine and positive regulation of TORC1 signaling. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q96FJ0|STAMBPL1
     1  MDQPFTVNSL KKLAAMPDHT DVSLSPEERV RALSKLGCNI TISEDITPRR YFRSGVEMER
    61  MASVYLEEGN LENAFVLYNK FITLFVEKLP NHRDYQQCAV PEKQDIMKKL KEIAFPRTDE
   121  LKNDLLKKYN VEYQEYLQSK NKYKAEILKK LEHQRLIEAE RKRIAQMRQQ QLESEQFLFF
   181  EDQLKKQELA RGQMRSQQTS GLSEQIDGSA LSCFSTHQNN SLLNVFADQP NKSDATNYAS
   241  HSPPVNRALT PAATLSAVQN LVVEGLRCVV LPEDLCHKFL QLAESNTVRG IETCGILCGK
   301  LTHNEFTITH VIVPKQSAGP DYCDMENVEE LFNVQDQHDL LTLGWIHTHP TQTAFLSSVD
   361  LHTHCSYQLM LPEAIAIVCS PKHKDTGIFR LTNAGMLEVS ACKKKGFHPH TKEPRLFSIC
   421  KHVLVKDIKI IVLDLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAMBPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 23 nTPM
testis: 17 nTPM
lymph node: 15 nTPM
tonsil: 12 nTPM
cerebral cortex: 11 nTPM
ovary: 9.8 nTPM

Single-cell type

vascular smooth muscle cells: 338 nCPM
microglia: 149 nCPM
adrenal cortex cells: 135 nCPM
pericytes: 95 nCPM
late primary spermatocytes: 89 nCPM
ependymal cells: 78 nCPM

Immune cell

T-reg: 28 nTPM
plasmacytoid DC: 28 nTPM
NK-cell: 24 nTPM
memory B-cell: 18 nTPM
naive CD4 T-cell: 17 nTPM
memory CD4 T-cell: 16 nTPM

Brain region

cerebral cortex: 31 nTPM
basal ganglia: 24 nTPM
white matter: 24 nTPM
pons: 19 nTPM
cerebellum: 18 nTPM
spinal cord: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAMBPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAMBPL1 as an antibody target. Whether an autoantibody or antibody against STAMBPL1 could matter depends on whether native STAMBPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAMBPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAMBPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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