Seroatlas · Human Serome Atlas

PDLIM5

PDZ and LIM domain protein 5

Also known as: Enh, LIM, PDLI5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HC4
Gene
PDLIM5
Ensembl
ENSG00000163110
Chromosome
4
Canonical length
596 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane,Focal adhesion sites

OverviewNCBI Gene

This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

596 residues, UniProt reviewed canonical sequence.

>Q96HC4|PDLIM5
     1  MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG
    61  MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST
   121  NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH
   181  ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR
   241  KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA
   301  DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS
   361  PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC
   421  AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG
   481  RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG
   541  CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDLIM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
1,090 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 1,090 nTPM
  • heart muscle: 589 nTPM
  • tongue: 538 nTPM
  • smooth muscle: 99 nTPM
  • blood vessel: 98 nTPM
  • endometrium: 88 nTPM

Single-cell type

  • myonuclei: 5,564 nCPM
  • cardiomyocytes: 2,747 nCPM
  • pituicytes/fscs: 1,559 nCPM
  • podocytes: 1,122 nCPM
  • thymic myoid cells: 1,099 nCPM
  • prostatic glandular cells: 1,088 nCPM

Immune cell

  • basophil: 218 nTPM
  • non-classical monocyte: 45 nTPM
  • intermediate monocyte: 40 nTPM
  • classical monocyte: 23 nTPM
  • neutrophil: 22 nTPM
  • eosinophil: 21 nTPM

Brain region

  • choroid plexus: 182 nTPM
  • medulla oblongata: 71 nTPM
  • midbrain: 69 nTPM
  • hypothalamus: 64 nTPM
  • thalamus: 61 nTPM
  • basal ganglia: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDLIM5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDLIM5 as an antibody target. Whether an autoantibody or antibody against PDLIM5 could matter depends on whether native PDLIM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDLIM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDLIM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDLIM5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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