Seroatlas · Human Serome Atlas

FAM162A

Protein FAM162A

Also known as: C3orf28, E2IG5, F162A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A26
Gene: FAM162A
Ensembl: ENSG00000114023
Chromosome: 3
Canonical length: 154 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Involved in cellular response to hypoxia; positive regulation of apoptotic process; and positive regulation of release of cytochrome c from mitochondria. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q96A26|FAM162A
     1  MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGA PSRTYNRVPL
    61  HKPTDWQKKI LIWSGRFKKE DEIPETVSLE MLDAAKNKMR VKISYLMIAL TVVGCIFMVI
   121  EGKKAAQRHE TLTSLNLEKK ARLKEEAAMK AKTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM162A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 191 nTPM

Expression across tissuesHPA

Tissue

esophagus: 191 nTPM
liver: 184 nTPM
heart muscle: 160 nTPM
rectum: 135 nTPM
colon: 134 nTPM
tongue: 131 nTPM

Single-cell type

esophageal suprabasal cells: 1,360 nCPM
esophageal apical cells: 1,355 nCPM
parietal cells: 568 nCPM
colonocytes: 542 nCPM
esophageal basal cells: 441 nCPM
suprabasal keratinocytes: 394 nCPM

Immune cell

naive CD8 T-cell: 86 nTPM
MAIT T-cell: 85 nTPM
naive CD4 T-cell: 83 nTPM
myeloid DC: 81 nTPM
T-reg: 78 nTPM
memory CD4 T-cell: 78 nTPM

Brain region

hypothalamus: 31 nTPM
thalamus: 30 nTPM
spinal cord: 30 nTPM
basal ganglia: 28 nTPM
cerebellum: 28 nTPM
choroid plexus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM162A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM162A as an antibody target. Whether an autoantibody or antibody against FAM162A could matter depends on whether native FAM162A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM162A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM162A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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