Seroatlas · Human Serome Atlas

KLC3

Kinesin light chain 3

Also known as: KLC2L, KLC3_HUMAN, KLCt, KNS2B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P597
Gene: KLC3
Ensembl: ENSG00000104892
Chromosome: 19
Canonical length: 504 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q6P597|KLC3
     1  MSVQVAAPGS AGLGPERLSP EELVRQTRQV VQGLEALRAE HHGLAGHLAE ALAGQGPAAG
    61  LEMLEEKQQV VSHSLEAIEL GLGEAQVLLA LSAHVGALEA EKQRLRSQAR RLAQENVWLR
   121  EELEETQRRL RASEESVAQL EEEKRHLEFL GQLRQYDPPA ESQQSESPPR RDSLASLFPS
   181  EEEERKGPEA AGAAAAQQGG YEIPARLRTL HNLVIQYAGQ GRYEVAVPLC RQALEDLERS
   241  SGHCHPDVAT MLNILALVYR DQNKYKEATD LLHDALQIRE QTLGPEHPAV AATLNNLAVL
   301  YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFE DVERHYARAL
   361  SIYEALGGPH DPNVAKTKNN LASAYLKQNK YQQAEELYKE ILHKEDLPAP LGAPNTGTAG
   421  DAEQALRRSS SLSKIRESIR RGSEKLVSRL RGEAAAGAAG MKRAMSLNTL NVDAPRAPGT
   481  QFPSWHLDKA PRTLSASTQD LSPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

skin: 100 nTPM
esophagus: 25 nTPM
vagina: 20 nTPM
cervix: 12 nTPM
salivary gland: 11 nTPM
kidney: 4.7 nTPM

Single-cell type

suprabasal keratinocytes: 174 nCPM
basal keratinocytes: 120 nCPM
esophageal suprabasal cells: 101 nCPM
esophageal apical cells: 76 nCPM
esophageal basal cells: 60 nCPM
breast myoepithelial cells: 46 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.4 nTPM
naive B-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM

Brain region

cerebellum: 7 nTPM
basal ganglia: 6.7 nTPM
cerebral cortex: 5.9 nTPM
white matter: 5.8 nTPM
hippocampal formation: 5.2 nTPM
medulla oblongata: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: -1.37
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLC3 as an antibody target. Whether an autoantibody or antibody against KLC3 could matter depends on whether native KLC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...