Seroatlas · Human Serome Atlas

TRAPPC6A

Trafficking protein particle complex subunit 6A

Also known as: HSPC289, MGC2650, TPC6A_HUMAN, TRS33

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75865
Gene: TRAPPC6A
Ensembl: ENSG00000007255
Chromosome: 19
Canonical length: 159 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>O75865|TRAPPC6A
     1  MADTVLFEFL HTEMVAELWA HDPDPGPGGQ KMSLSVLEGM GFRVGQALGE RLPRETLAFR
    61  EELDVLKFLC KDLWVAVFQK QMDSLRTNHQ GTYVLQDNSF PLLLPMASGL QYLEEAPKFL
   121  AFTCGLLRGA LYTLGIESVV TASVAALPVC KFQVVIPKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

kidney: 63 nTPM
liver: 58 nTPM
skin: 53 nTPM
spinal cord: 48 nTPM
bone marrow: 46 nTPM
spleen: 41 nTPM

Single-cell type

late spermatids: 164 nCPM
epididymal principal cells: 159 nCPM
cytotrophoblasts: 147 nCPM
epididymal efferent duct absorptive cells: 141 nCPM
migrating cytotrophoblasts: 110 nCPM
fallopian secretory cells: 101 nCPM

Immune cell

NK-cell: 114 nTPM
T-reg: 113 nTPM
naive CD4 T-cell: 111 nTPM
memory CD4 T-cell: 106 nTPM
naive CD8 T-cell: 95 nTPM
MAIT T-cell: 95 nTPM

Brain region

white matter: 39 nTPM
medulla oblongata: 35 nTPM
basal ganglia: 32 nTPM
cerebellum: 30 nTPM
pons: 29 nTPM
spinal cord: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC6A as an antibody target. Whether an autoantibody or antibody against TRAPPC6A could matter depends on whether native TRAPPC6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC6A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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