Seroatlas · Human Serome Atlas

TRAPPC2B

Trafficking protein particle complex subunit 2B

Also known as: MIP-2A, SEDLP, SEDLP1, TPC2B_HUMAN, TRAPPC2P1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DI82
Gene: TRAPPC2B
Ensembl: ENSG00000256060
Chromosome: 19
Canonical length: 140 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Endoplasmic reticulum,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>P0DI82|TRAPPC2B
     1  MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY
    61  LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT DVYDLYIKFS MNPFYEPNSP
   121  IRSSAFDRKV QFLGKKHLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 27 nTPM
testis: 21 nTPM
choroid plexus: 20 nTPM
adrenal gland: 19 nTPM
heart muscle: 17 nTPM
tongue: 16 nTPM

Single-cell type

early spermatids: 22 nCPM
late primary spermatocytes: 15 nCPM
gastric chief cells: 7.6 nCPM
megakaryocytes: 6.2 nCPM
endometrial secretory cells: 4.9 nCPM
oocytes: 4.6 nCPM

Immune cell

basophil: 69 nTPM
naive B-cell: 49 nTPM
memory B-cell: 46 nTPM
NK-cell: 44 nTPM
plasmacytoid DC: 38 nTPM
eosinophil: 31 nTPM

Brain region

cerebellum: 13 nTPM
choroid plexus: 11 nTPM
hypothalamus: 10 nTPM
pons: 9.5 nTPM
cerebral cortex: 9.3 nTPM
white matter: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0.03

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC2B as an antibody target. Whether an autoantibody or antibody against TRAPPC2B could matter depends on whether native TRAPPC2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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