Seroatlas · Human Serome Atlas

COG7

Conserved oligomeric Golgi complex subunit 7

Also known as: COG7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P83436
Gene
COG7
Ensembl
ENSG00000168434
Chromosome
16
Canonical length
770 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

770 residues, UniProt reviewed canonical sequence.

>P83436|COG7
     1  MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE VNHAVEETSH
    61  QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD TSQSMQVLVE IDQVKSRMQL
   121  AAESLQEADK WSTLSADIEE TFKTQDIAVI SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL
   181  KNRLEALASP QIVAAFTSQA VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC
   241  QSDLSLDRQL TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN
   301  GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA VYDPYKPYQL
   361  KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG LASAAVDRCV RFTNGLGTCG
   421  LLSALKSLFA KYVSDFTSTL QSIRKKCKLD HIPPNSLFQE DWTAFQNSIR IIATCGELLR
   481  HCGDFEQQLA NRILSTAGKY LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP
   541  AEYASLMEIL YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM
   601  DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS ALELALHAGK
   661  LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI PELSPHSAKQ LATDIDYLIN
   721  VMDALGLQPS RTLQHIVTLL KTRPEDYRQV SKGLPRRLAT TVATMRSVNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 22 nTPM
  • choroid plexus: 17 nTPM
  • prostate: 16 nTPM
  • parathyroid gland: 15 nTPM
  • fallopian tube: 14 nTPM
  • thyroid gland: 14 nTPM

Single-cell type

  • lactotrophs: 140 nCPM
  • somatotrophs: 131 nCPM
  • respiratory ciliated cells: 122 nCPM
  • choroid plexus epithelial cells: 102 nCPM
  • thyrotrophs: 102 nCPM
  • renal connecting tubule cells: 88 nCPM

Immune cell

  • non-classical monocyte: 10 nTPM
  • naive CD8 T-cell: 8.6 nTPM
  • basophil: 8.4 nTPM
  • myeloid DC: 8 nTPM
  • intermediate monocyte: 7.7 nTPM
  • MAIT T-cell: 7.6 nTPM

Brain region

  • choroid plexus: 37 nTPM
  • white matter: 23 nTPM
  • cerebral cortex: 23 nTPM
  • midbrain: 22 nTPM
  • pons: 21 nTPM
  • basal ganglia: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COG7.

Disease | AllUniProt

Conditions COG7 is implicated in, by any mechanism.

  • Congenital disorder of glycosylation 2E (CDG2E) MIM:608779

Disease | GeneticClinVar

28 pathogenic / likely-pathogenic of 636 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • COG7 congenital disorder of glycosylation

Disease | ImmuneIEDB

Conditions an epitope on COG7 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Conserved oligomeric Golgi complex subunit 7
  • Golgi complex component 7 (COG7)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COG7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COG7 as an antibody target. Whether an autoantibody or antibody against COG7 could matter depends on whether native COG7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COG7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COG7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COG7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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