Seroatlas · Human Serome Atlas

SPINDOC

Spindlin interactor and repressor of chromatin-binding protein

Also known as: C11orf84, SPIN-DOC, SPNDC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUA3
Gene: SPINDOC
Ensembl: ENSG00000168005
Chromosome: 11
Canonical length: 381 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Involved in DNA damage response and negative regulation of DNA-templated transcription. Is active in nucleus and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q9BUA3|SPINDOC
     1  MALKAEGAAL DCFEVTLKCE EGEDEEEAMV VAVIPRPEPM LRVTQQEKTP PPRPSPLEAG
    61  SDGCEEPKQQ VSWEQEFLVG SSPGGSGRAL CMVCGAEIRA PSADTARSHI LEQHPHTLDL
   121  SPSEKSNILE AWSEGVALLQ DVRAEQPSPP NSDSGQDAHP DPDANPDAAR MPAEIVVLLD
   181  SEDNPSLPKR SRPRGLRPLE LPAVPATEPG NKKPRGQRWK EPPGEEPVRK KRGRPMTKNL
   241  DPDPEPPSPD SPTETFAAPA EVRHFTDGSF PAGFVLQLFS HTQLRGPDSK DSPKDREVAE
   301  GGLPRAESPS PAPPPGLRGT LDLQVIRVRM EEPPAVSLLQ DWSRHPQGTK RVGAGDTSDW
   361  PTVLSESSTT VAGKPEKGNG V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPINDOC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

testis: 38 nTPM
placenta: 25 nTPM
cerebellum: 19 nTPM
colon: 19 nTPM
endometrium: 18 nTPM
prostate: 18 nTPM

Single-cell type

tuft cells: 35 nCPM
cytotrophoblasts: 28 nCPM
breast myoepithelial cells: 24 nCPM
megakaryocyte progenitors: 22 nCPM
innate lymphoid cells: 21 nCPM
endometrial secretory cells: 17 nCPM

Immune cell

basophil: 0.5 nTPM
gdT-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
memory B-cell: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

hypothalamus: 45 nTPM
cerebral cortex: 38 nTPM
pons: 38 nTPM
cerebellum: 37 nTPM
midbrain: 35 nTPM
basal ganglia: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 0.99
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPINDOC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPINDOC as an antibody target. Whether an autoantibody or antibody against SPINDOC could matter depends on whether native SPINDOC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPINDOC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPINDOC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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