Seroatlas · Human Serome Atlas

TLE3

Transducin-like enhancer protein 3

Also known as: ESG, ESG3, GRG3, HsT18976, KIAA1547, TLE3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q04726
Gene
TLE3
Ensembl
ENSG00000140332
Chromosome
15
Canonical length
772 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

772 residues, UniProt reviewed canonical sequence.

>Q04726|TLE3
     1  MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH
    61  YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN
   121  AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV
   181  KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS
   241  DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK
   301  TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI GIMASALRTP
   361  ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS AAAAAAAAAY GRSPMVSFGA
   421  VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF HVSADGQMQP VPFPHDALAG PGIPRHARQI
   481  NTLSHGEVVC AVTISNPTRH VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL
   541  LPDGRTLIVG GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI
   601  AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG RQLQQHDFTS
   661  QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE SCVLSLKFAY CGKWFVSTGK
   721  DNLLNAWRTP YGASIFQSKE SSSVLSCDIS ADDKYIVTGS GDKKATVYEV IY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 62 nTPM
  • esophagus: 31 nTPM
  • skin: 28 nTPM
  • spleen: 22 nTPM
  • prostate: 22 nTPM
  • testis: 21 nTPM

Single-cell type

  • neutrophils: 596 nCPM
  • late spermatids: 136 nCPM
  • monocytes: 123 nCPM
  • esophageal apical cells: 113 nCPM
  • suprabasal keratinocytes: 104 nCPM
  • extravillous trophoblasts: 100 nCPM

Immune cell

  • neutrophil: 49 nTPM
  • memory B-cell: 10 nTPM
  • plasmacytoid DC: 8.8 nTPM
  • non-classical monocyte: 5.2 nTPM
  • naive B-cell: 4.9 nTPM
  • intermediate monocyte: 4.8 nTPM

Brain region

  • hypothalamus: 42 nTPM
  • thalamus: 41 nTPM
  • medulla oblongata: 41 nTPM
  • midbrain: 38 nTPM
  • spinal cord: 37 nTPM
  • cerebral cortex: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.07
gnomAD pLI
1
gnomAD missense Z
3.72
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TLE3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLE3 as an antibody target. Whether an autoantibody or antibody against TLE3 could matter depends on whether native TLE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLE3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TLE3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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