Catenin binding domain superfamily
IPR027397
Definition
This superfamily represents the catenin binding domain. Proteins containing this domain include cadherins, desmocollins, desmoglein and transcription factor 7-like proteins [[cite:PMID:10080941], [cite:PMID:11136974], [cite:PMID:11348595], [cite:PMID:21075118]]. Cadherins and catenins play important roles in the adherents junctions in animal cells. The cadherin-catenin complex is responsible for coupling Ca(2+)-dependent intercellular junctions with actin dynamics and signalling pathways. Desmosomal cadherins are TM protein components of desmosomes (for review, see [[cite:PMID:11509257], [cite:PMID:12126234], [cite:PMID:11171365]]), whose extracellular cadherin repeats are responsible for adhesion and whose intracellular regions interact with intermediate filaments via desmosomal plaque proteins plakoglobin, plakobilin and desmoplakin. They are believed to play a wider role in regulation of epithelial differentiation PMID:12126234. Two sub-families of desmosomal cadherin have been identified, desmocollin (DSC) and desmoglein (DSG).
29 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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