Seroatlas · Human Serome Atlas

ZMAT3

Zinc finger matrin-type protein 3

Also known as: FLJ12296, MGC10613, PAG608, WIG-1, WIG1, ZMAT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HA38
Gene
ZMAT3
Ensembl
ENSG00000172667
Chromosome
3
Canonical length
289 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q9HA38|ZMAT3
     1  MILLQHAVLP PPKQPSPSPP MSVATRSTGT LQLPPQKPFG QEASLPLAGE EELSKGGEQD
    61  CALEELCKPL YCKLCNVTLN SAQQAQAHYQ GKNHGKKLRN YYAANSCPPP ARMSNVVEPA
   121  ATPVVPVPPQ MGSFKPGGRV ILATENDYCK LCDASFSSPA VAQAHYQGKN HAKRLRLAEA
   181  QSNSFSESSE LGQRRARKEG NEFKMMPNRR NMYTVQNNSA GPYFNPRSRQ RIPRDLAMCV
   241  TPSGQFYCSM CNVGAGEEME FRQHLESKQH KSKVSEQRYR NEMENLGYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 17 nTPM
  • liver: 12 nTPM
  • basal ganglia: 11 nTPM
  • amygdala: 11 nTPM
  • smooth muscle: 11 nTPM
  • midbrain: 9.9 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 188 nCPM
  • microglia: 169 nCPM
  • bergmann glia: 128 nCPM
  • melanocytes: 118 nCPM
  • adrenal medulla cells: 117 nCPM
  • choroid plexus epithelial cells: 115 nCPM

Immune cell

  • naive CD4 T-cell: 2.1 nTPM
  • basophil: 1.9 nTPM
  • gdT-cell: 1.8 nTPM
  • naive B-cell: 1.8 nTPM
  • eosinophil: 1.7 nTPM
  • NK-cell: 1.6 nTPM

Brain region

  • cerebral cortex: 63 nTPM
  • midbrain: 61 nTPM
  • thalamus: 60 nTPM
  • pons: 60 nTPM
  • hypothalamus: 59 nTPM
  • white matter: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.78
DepMap mean gene effect
0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMAT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMAT3 as an antibody target. Whether an autoantibody or antibody against ZMAT3 could matter depends on whether native ZMAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMAT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZMAT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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