Seroatlas · Human Serome Atlas

SYVN1

E3 ubiquitin-protein ligase synoviolin

Also known as: DER3, HRD1, SYVN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86TM6
Gene
SYVN1
Ensembl
ENSG00000162298
Chromosome
11
Canonical length
617 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q86TM6|SYVN1
     1  MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA FVLVFLLGKV
    61  MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL LFLKCFHWLA
   121  EDRVDFMERS PNISWLFHCR IVSLMFLLGI LDFLFVSHAY HSILTRGASV QLVFGFEYAI
   181  LMTMVLTIFI KYVLHSVDLQ SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF
   241  PLFAIRPMYL AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT
   301  GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD QGPPPAPHPP
   361  PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS GEAVAPPSTS AAALSRPSGA
   421  ATTTAAGTSA TAASATASGP GSGSAPEAGP APGFPFPPPW MGMPLPPPFA FPPMPVPPAG
   481  FAGLTPEELR ALEGHERQHL EARLQSLRNI HTLLDAAMLQ INQYLTVLAS LGPPRPATSV
   541  NSTEETATTV VAAASSTSIP SSEATTPTPG ASPPAPEMER PPAPESVGTE EMPEDGEPDA
   601  AELRRRRLQK LESPVAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYVN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
111 nTPM

Expression across tissuesHPA

Tissue

  • liver: 111 nTPM
  • pancreas: 88 nTPM
  • tonsil: 76 nTPM
  • lymph node: 57 nTPM
  • salivary gland: 53 nTPM
  • spleen: 49 nTPM

Single-cell type

  • plasma cells: 98 nCPM
  • hepatocytes: 90 nCPM
  • breast lactating cells: 62 nCPM
  • syncytiotrophoblasts: 54 nCPM
  • epididymal principal cells: 53 nCPM
  • esophageal apical cells: 49 nCPM

Immune cell

  • naive B-cell: 23 nTPM
  • memory B-cell: 22 nTPM
  • plasmacytoid DC: 19 nTPM
  • basophil: 17 nTPM
  • eosinophil: 14 nTPM
  • classical monocyte: 7.4 nTPM

Brain region

  • medulla oblongata: 58 nTPM
  • choroid plexus: 55 nTPM
  • midbrain: 52 nTPM
  • basal ganglia: 52 nTPM
  • pons: 51 nTPM
  • white matter: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
2.18
DepMap mean gene effect
-0.56
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYVN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYVN1 as an antibody target. Whether an autoantibody or antibody against SYVN1 could matter depends on whether native SYVN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYVN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYVN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYVN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...