Seroatlas · Human Serome Atlas

UBXN8

UBX domain-containing protein 8

Also known as: D8S2298E, REP8, UBXD6, UBXN8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00124
Gene: UBXN8
Ensembl: ENSG00000104691
Chromosome: 8
Canonical length: 270 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli,Endoplasmic reticulum
Secretome location: Intracellular and membrane

OverviewNCBI Gene

p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>O00124|UBXN8
     1  MASRGVVGIF FLSAVPLVCL ELRRGIPDIG IKDFLLLCGR ILLLLALLTL IISVTTSWLN
    61  SFKSPQVYLK EEEEKNEKRQ KLVRKKQQEA QGEKASRYIE NVLKPHQEMK LRKLEERFYQ
   121  MTGEAWKLSS GHKLGGDEGT SQTSFETSNR EAAKSQNLPK PLTEFPSPAE QPTCKEIPDL
   181  PEEPSQTAEE VVTVALRCPS GNVLRRRFLK SYSSQVLFDW MTRIGYHISL YSLSTSFPRR
   241  PLAVEGGQSL EDIGITVDTV LILEEKEQTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 117 nTPM

Expression across tissuesHPA

Tissue

ovary: 117 nTPM
testis: 62 nTPM
epididymis: 55 nTPM
liver: 42 nTPM
pancreas: 36 nTPM
thyroid gland: 27 nTPM

Single-cell type

granulosa cells: 365 nCPM
late spermatids: 291 nCPM
early spermatids: 241 nCPM
ovarian stromal cells: 152 nCPM
hepatocytes: 89 nCPM
cone photoreceptor cells: 75 nCPM

Immune cell

plasmacytoid DC: 6.5 nTPM
gdT-cell: 6.3 nTPM
memory CD8 T-cell: 5.8 nTPM
naive CD8 T-cell: 5.6 nTPM
MAIT T-cell: 5.4 nTPM
myeloid DC: 5.2 nTPM

Brain region

cerebellum: 131 nTPM
pons: 121 nTPM
basal ganglia: 114 nTPM
hippocampal formation: 110 nTPM
cerebral cortex: 109 nTPM
amygdala: 105 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN8 as an antibody target. Whether an autoantibody or antibody against UBXN8 could matter depends on whether native UBXN8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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