CREB3L3

Protein identityUniProt · HPA

UniProt accession

Q68CJ9

Gene

CREB3L3

Ensembl

ENSG00000060566

Chromosome

19

Canonical length

461 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q68CJ9|CREB3L3
     1  MNTDLAAGKM ASAACSMDPI DSFELLDLLF DRQDGILRHV ELGEGWGHVK DQQVLPNPDS
    61  DDFLSSILGS GDSLPSSPLW SPEGSDSGIS EDLPSDPQDT PPRSGPATSP AGCHPAQPGK
   121  GPCLSYHPGN SCSTTTPGPV IQVPEASVTI DLEMWSPGGR ICAEKPADPV DLSPRCNLTV
   181  KDLLLSGSSG DLQQHHLGAS YLLRPGAGHC QELVLTEDEK KLLAKEGITL PTQLPLTKYE
   241  ERVLKKIRRK IRNKQSAQES RKKKKEYIDG LETRMSACTA QNQELQRKVL HLEKQNLSLL
   301  EQLKKLQAIV VQSTSKSAQT GTCVAVLLLS FALIILPSIS PFGPNKTESP GDFAPVRVFS
   361  RTLHNDAASR VAADAVPGSE APGPRPEADT TREESPGSPG ADWGFQDTAN LTNSTEELDN
   421  ATLVLRNATE GLGQVALLDW VAPGPSTGSG RAGLEAAGDE L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREB3L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

381 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CREB3L3.

Disease | AllUniProt

Conditions CREB3L3 is implicated in, by any mechanism.

• Hypertriglyceridemia 2 (HYTG2) MIM:619324

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 332 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hypertriglyceridemia 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.47

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of acute inflammatory response
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II
• response to endoplasmic reticulum stress
• response to unfolded protein

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• identical protein binding
• protein heterodimerization activity
• protein homodimerization activity
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• transcription cis-regulatory region binding

Cellular components

• chromatin
• cytosol
• endoplasmic reticulum
• endoplasmic reticulum membrane
• Golgi membrane
• membrane
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Basic-leucine zipper domain
• Basic-leucine zipper domain superfamily
• cAMP-responsive element-binding ATF subfamily
• bZIP transcription factor

KeywordsUniProt

• Activator
• DNA-binding
• Endoplasmic reticulum
• Glycoprotein
• Isopeptide bond
• Membrane
• Nucleus
• Phosphoprotein
• Signal-anchor
• Transcription
• Transcription regulation
• Transmembrane
• Transmembrane helix
• Ubl conjugation
• Unfolded protein response

InteractionsUniProt · HPA

Protein binding partners of CREB3L3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATF6
• SYVN1