Seroatlas · Human Serome Atlas

OS9

Protein OS-9

Also known as: ERLEC2, OS-9, OS9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13438
Gene: OS9
Ensembl: ENSG00000135506
Chromosome: 12
Canonical length: 667 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Endoplasmic reticulum
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

667 residues, UniProt reviewed canonical sequence.

>Q13438|OS9
     1  MAAETLLSSL LGLLLLGLLL PASLTGGVGS LNLEELSEMR YGIEILPLPV MGGQSQSSDV
    61  VIVSSKYKQR YECRLPAGAI HFQREREEET PAYQGPGIPE LLSPMRDAPC LLKTKDWWTY
   121  EFCYGRHIQQ YHMEDSEIKG EVLYLGYYQS AFDWDDETAK ASKQHRLKRY HSQTYGNGSK
   181  CDLNGRPREA EVRFLCDEGA GISGDYIDRV DEPLSCSYVL TIRTPRLCPH PLLRPPPSAA
   241  PQAILCHPSL QPEEYMAYVQ RQADSKQYGD KIIEELQDLG PQVWSETKSG VAPQKMAGAS
   301  PTKDDSKDSD FWKMLNEPED QAPGGEEVPA EEQDPSPEAA DSASGAPNDF QNNVQVKVIR
   361  SPADLIRFIE ELKGGTKKGK PNIGQEQPVD DAAEVPQREP EKERGDPERQ REMEEEEDED
   421  EDEDEDEDER QLLGEFEKEL EGILLPSDRD RLRSEVKAGM ERELENIIQE TEKELDPDGL
   481  KKESERDRAM LALTSTLNKL IKRLEEKQSP ELVKKHKKKR VVPKKPPPSP QPTEEDPEHR
   541  VRVRVTKLRL GGPNQDLTVL EMKRENPQLK QIEGLVKELL EREGLTAAGK IEIKIVRPWA
   601  EGTEEGARWL TDEDTRNLKE IFFNILVPGA EEAQKERQRQ KELESNYRRV WGSPGGEGTG
   661  DLDEFDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OS9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 261 nTPM

Expression across tissuesHPA

Tissue

pancreas: 261 nTPM
liver: 253 nTPM
choroid plexus: 219 nTPM
salivary gland: 184 nTPM
parathyroid gland: 170 nTPM
ovary: 161 nTPM

Single-cell type

neutrophils: 301 nCPM
esophageal apical cells: 270 nCPM
lacrimal acinar cells: 247 nCPM
syncytiotrophoblasts: 242 nCPM
plasma cells: 207 nCPM
extravillous trophoblasts: 197 nCPM

Immune cell

eosinophil: 280 nTPM
neutrophil: 253 nTPM
classical monocyte: 247 nTPM
total PBMC: 222 nTPM
intermediate monocyte: 219 nTPM
non-classical monocyte: 188 nTPM

Brain region

choroid plexus: 150 nTPM
hypothalamus: 101 nTPM
thalamus: 96 nTPM
medulla oblongata: 91 nTPM
pons: 84 nTPM
white matter: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

carbohydrate binding
protease binding
glycosylation-dependent protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OS9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OS9 as an antibody target. Whether an autoantibody or antibody against OS9 could matter depends on whether native OS9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OS9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OS9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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