Seroatlas · Human Serome Atlas

FAM8A1

Protein FAM8A1

Also known as: AHCP, FA8A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBU6
Gene: FAM8A1
Ensembl: ENSG00000137414
Chromosome: 6
Canonical length: 413 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in ERAD pathway. Part of Hrd1p ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>Q9UBU6|FAM8A1
     1  MAEGPEEARG HPPGQDDGGG DHEPVPSLRG PPTTAVPCPR DDPQAEPQAP GRPTAPGLAA
    61  AAAADKLEPP RELRKRGEAA SGSGAELQEQ AGCEAPEAAA PRERPARLSA REYSRQVHEW
   121  LWQSYCGYLT WHSGLAAFPA YCSPQPSPQS FPSGGAAVPQ AAAPPPPQLG YYNPFYFLSP
   181  GAAGPDPRTA AGISTPAPVA GLGPRAPHVQ ASVRATPVTR VGSAAPSRSP SETGRQAGRE
   241  YVIPSLAHRF MAEMVDFFIL FFIKATIVLS IMHLSGIKDI SKFAMHYIIE EIDEDTSMED
   301  LQKMMVVALI YRLLVCFYEI ICIWGAGGAT PGKFLLGLRV VTCDTSVLIA PSRVLVIPSS
   361  NVSITTSTIR ALIKNFSIAS FFPAFITLLF FQHNRTAYDI VAGTIVVKRN GVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM8A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 83 nTPM

Expression across tissuesHPA

Tissue

liver: 83 nTPM
bone marrow: 34 nTPM
endometrium: 29 nTPM
ovary: 29 nTPM
retina: 29 nTPM
smooth muscle: 27 nTPM

Single-cell type

early spermatids: 911 nCPM
late spermatids: 269 nCPM
late primary spermatocytes: 267 nCPM
neutrophils: 240 nCPM
neutrophil progenitors: 122 nCPM
hepatocytes: 89 nCPM

Immune cell

neutrophil: 5 nTPM
basophil: 2.8 nTPM
NK-cell: 1.5 nTPM
eosinophil: 1.2 nTPM
MAIT T-cell: 1.2 nTPM
gdT-cell: 1.1 nTPM

Brain region

hypothalamus: 39 nTPM
white matter: 39 nTPM
spinal cord: 37 nTPM
cerebellum: 35 nTPM
medulla oblongata: 33 nTPM
pons: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.02
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ERAD pathway

Cellular components

Hrd1p ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

RDD
Protein FAM8A1
RDD family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM8A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM8A1 as an antibody target. Whether an autoantibody or antibody against FAM8A1 could matter depends on whether native FAM8A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM8A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM8A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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