Seroatlas · Human Serome Atlas

UBXN6

UBX domain-containing protein 6

Also known as: UBXD1, UBXDC2, UBXN6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZV1
Gene: UBXN6
Ensembl: ENSG00000167671
Chromosome: 19
Canonical length: 441 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables ATPase binding activity. Involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Located in bounding membrane of organelle and cytosol. Part of endosome and protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q9BZV1|UBXN6
     1  MKKFFQEFKA DIKFKSAGPG QKLKESVGEK AHKEKPNQPA PRPPRQGPTN EAQMAAAAAL
    61  ARLEQKQSRA WGPTSQDTIR NQVRKELQAE ATVSGSPEAP GTNVVSEPRE EGSAHLAVPG
   121  VYFTCPLTGA TLRKDQRDAC IKEAILLHFS TDPVAASIMK IYTFNKDQDR VKLGVDTIAK
   181  YLDNIHLHPE EEKYRKIKLQ NKVFQERINC LEGTHEFFEA IGFQKVLLPA QDQEDPEEFY
   241  VLSETTLAQP QSLERHKEQL LAAEPVRAKL DRQRRVFQPS PLASQFELPG DFFNLTAEEI
   301  KREQRLRSEA VERLSVLRTK AMREKEEQRG LRKYNYTLLR VRLPDGCLLQ GTFYARERLG
   361  AVYGFVREAL QSDWLPFELL ASGGQKLSED ENLALNECGL VPSALLTFSW DMAVLEDIKA
   421  AGAEPDSILK PELLSAIEKL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 205 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 205 nTPM
adrenal gland: 182 nTPM
testis: 165 nTPM
cerebral cortex: 141 nTPM
pituitary gland: 137 nTPM
hippocampal formation: 119 nTPM

Single-cell type

late spermatids: 2,484 nCPM
late primary spermatocytes: 328 nCPM
early spermatids: 299 nCPM
platelets: 164 nCPM
enterocytes: 130 nCPM
megakaryocytes: 130 nCPM

Immune cell

eosinophil: 10 nTPM
plasmacytoid DC: 10 nTPM
intermediate monocyte: 8 nTPM
myeloid DC: 6.7 nTPM
neutrophil: 6.7 nTPM
classical monocyte: 6.6 nTPM

Brain region

hippocampal formation: 132 nTPM
cerebral cortex: 131 nTPM
midbrain: 120 nTPM
choroid plexus: 117 nTPM
pons: 115 nTPM
amygdala: 108 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATPase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN6 as an antibody target. Whether an autoantibody or antibody against UBXN6 could matter depends on whether native UBXN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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