ANGPT2

Protein identityUniProt · HPA

UniProt accession

O15123

Gene

ANGPT2

Ensembl

ENSG00000091879

Chromosome

8

Canonical length

496 aa

Protein class

Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins, RAS pathway related proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>O15123|ANGPT2
     1  MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM DNCRSSSSPY
    61  VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY IQDNMKKEMV EIQQNAVQNQ
   121  TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL NQTTRLELQL LEHSLSTNKL EKQILDQTSE
   181  INKLQDKNSF LEKKVLAMED KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN
   241  NSVLQKQQHD LMETVNNLLT MMSTSNSAKD PTVAKEEQIS FRDCAEVFKS GHTTNGIYTL
   301  TFPNSTEEIK AYCDMEAGGG GWTIIQRRED GSVDFQRTWK EYKVGFGNPS GEYWLGNEFV
   361  SQLTNQQRYV LKIHLKDWEG NEAYSLYEHF YLSSEELNYR IHLKGLTGTA GKISSISQPG
   421  NDFSTKDGDN DKCICKCSQM LTGGWWFDAC GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS
   481  GYSLKATTMM IRPADF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANGPT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

15 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANGPT2.

Disease | AllUniProt

Conditions ANGPT2 is implicated in, by any mechanism.

• Lymphatic malformation 10 (LMPHM10) MIM:619369

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 121 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Lymphatic malformation 10

ReferencesPubMed · IEDB

Publications for ANGPT2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.38

gnomAD pLI

0.83

gnomAD missense Z

-0.53

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• animal organ regeneration
• blood coagulation
• cellular response to growth factor stimulus
• gene expression
• germ cell development
• glomerulus vasculature development
• maternal process involved in female pregnancy
• negative regulation of angiogenesis
• negative regulation of blood vessel endothelial cell migration
• negative regulation of cell-substrate adhesion
• positive regulation of angiogenesis
• positive regulation of coagulation
• response to activity
• response to glucose
• response to hypoxia
• response to mechanical stimulus
• signal transduction
• Tie signaling pathway
• negative regulation of positive chemotaxis

Molecular functions

• metal ion binding
• receptor ligand activity
• receptor tyrosine kinase binding
• signaling receptor binding

Cellular components

• cell projection
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
• Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
• Fibrinogen, conserved site
• Fibrinogen-like, C-terminal
• Fibrinogen/angiopoietin-like
• Angiopoietin-1/2/4 domain
• Fibrinogen beta and gamma chains, C-terminal globular domain
• ANG-1-like domain

KeywordsUniProt

• Angiogenesis
• Calcium
• Coiled coil
• Developmental protein
• Differentiation
• Disulfide bond
• Glycoprotein
• Metal-binding
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of ANGPT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ITGA5
• THBD
• SVEP1
• TEK