Seroatlas · Human Serome Atlas

SUPT4H1

Transcription elongation factor SPT4

Also known as: Spt4, SPT4H, SPT4H_HUMAN, Supt4a, SUPT4H

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63272
Gene: SUPT4H1
Ensembl: ENSG00000213246
Chromosome: 17
Canonical length: 117 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P63272|SUPT4H1
     1  MALETVPKDL RHLRACLLCS LVKTIDQFEY DGCDNCDAYL QMKGNREMVY DCTSSSFDGI
    61  IAMMSPEDSW VSKWQRVSNF KPGVYAVSVT GRLPQGIVRE LKSRGVAYKS RDTAIKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUPT4H1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 134 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 134 nTPM
lymph node: 98 nTPM
kidney: 75 nTPM
adrenal gland: 67 nTPM
spleen: 67 nTPM
thymus: 63 nTPM

Single-cell type

platelets: 23 nCPM
paneth cells: 16 nCPM
bergmann glia: 12 nCPM
parietal cells: 12 nCPM
microglia: 11 nCPM
oligodendrocytes: 10 nCPM

Immune cell

neutrophil: 364 nTPM
eosinophil: 245 nTPM
total PBMC: 243 nTPM
basophil: 241 nTPM
non-classical monocyte: 220 nTPM
intermediate monocyte: 215 nTPM

Brain region

cerebral cortex: 44 nTPM
cerebellum: 44 nTPM
white matter: 42 nTPM
basal ganglia: 40 nTPM
spinal cord: 39 nTPM
hypothalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.52
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Transcription initiation Spt4
Spt4/RpoE2 zinc finger
Spt4 superfamily
Spt4/RpoE2 zinc finger

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUPT4H1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUPT4H1 as an antibody target. Whether an autoantibody or antibody against SUPT4H1 could matter depends on whether native SUPT4H1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUPT4H1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUPT4H1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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