Seroatlas · Human Serome Atlas

IWS1

Protein IWS1 homolog

Also known as: DKFZp761G0123, FLJ10006, FLJ14655, FLJ32319, IWS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96ST2
Gene
IWS1
Ensembl
ENSG00000163166
Chromosome
2
Canonical length
819 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Involved in regulation of mRNA export from nucleus; regulation of mRNA processing; and transcription elongation-coupled chromatin remodeling. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

819 residues, UniProt reviewed canonical sequence.

>Q96ST2|IWS1
     1  MDSEYYSGDQ SDDGGATPVQ DERDSGSDGE DDVNEQHSGS DTGSVERHSE NETSDREDGL
    61  PKGHHVTDSE NDEPLNLNAS DSESEELHRQ KDSDSESEER AEPPASDSEN EDVNQHGSDS
   121  ESEETRKLPG SDSENEELLN GHASDSENED VGKHPASDSE IEELQKSPAS DSETEDALKP
   181  QISDSESEEP PRHQASDSEN EEPPKPRMSD SESEELPKPQ VSDSESEEPP RHQASDSENE
   241  ELPKPRISDS ESEDPPRHQA SDSENEELPK PRISDSESED PPRNQASDSE NEELPKPRVS
   301  DSESEGPQKG PASDSETEDA SRHKQKPESD DDSDRENKGE DTEMQNDSFH SDSHMDRKKF
   361  HSSDSEEEEH KKQKMDSDED EKEGEEEKVA KRKAAVLSDS EDEEKASAKK SRVVSDADDS
   421  DSDAVSDKSG KREKTIASDS EEEAGKELSD KKNEEKDLFG SDSESGNEEE NLIADIFGES
   481  GDEEEEEFTG FNQEDLEEEK GETQVKEAED SDSDDNIKRG KHMDFLSDFE MMLQRKKSMS
   541  GKRRRNRDGG TFISDADDVV SAMIVKMNEA AEEDRQLNNQ KKPALKKLTL LPAVVMHLKK
   601  QDLKETFIDS GVMSAIKEWL SPLPDRSLPA LKIREELLKI LQELPSVSQE TLKHSGIGRA
   661  VMYLYKHPKE SRSNKDMAGK LINEWSRPIF GLTSNYKGMT REEREQRDLE QMPQRRRMNS
   721  TGGQTPRRDL EKVLTGEEKA LRPGDPGFCA RARVPMPSNK DYVVRPKWNV EMESSRFQAT
   781  SKKGISRLDK QMRKFTDIRK KSRSAHAVKI SIEGNKMPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IWS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 73 nTPM
  • heart muscle: 46 nTPM
  • liver: 40 nTPM
  • tongue: 37 nTPM
  • midbrain: 33 nTPM
  • spinal cord: 32 nTPM

Single-cell type

  • myonuclei: 199 nCPM
  • somatotrophs: 189 nCPM
  • syncytiotrophoblasts: 168 nCPM
  • distal convoluted tubule cells: 135 nCPM
  • oligodendrocytes: 135 nCPM
  • ependymal cells: 127 nCPM

Immune cell

  • eosinophil: 19 nTPM
  • non-classical monocyte: 17 nTPM
  • naive B-cell: 15 nTPM
  • NK-cell: 15 nTPM
  • intermediate monocyte: 15 nTPM
  • neutrophil: 14 nTPM

Brain region

  • white matter: 48 nTPM
  • basal ganglia: 37 nTPM
  • midbrain: 36 nTPM
  • thalamus: 36 nTPM
  • hypothalamus: 36 nTPM
  • pons: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
2.38
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IWS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IWS1 as an antibody target. Whether an autoantibody or antibody against IWS1 could matter depends on whether native IWS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IWS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IWS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IWS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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