Seroatlas · Human Serome Atlas

WDR43

WD repeat-containing protein 43

Also known as: KIAA0007, NET12, UTP5, WDR43_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15061
Gene
WDR43
Ensembl
ENSG00000163811
Chromosome
2
Canonical length
677 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Located in fibrillar center. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>Q15061|WDR43
     1  MAAGGGGSCD PLAPAGVPCA FSPHSQAYFA LASTDGHLRV WETANNRLHQ EYVPSAHLSG
    61  TCTCLAWAPA RLQAKESPQR KKRKSEAVGM SNQTDLLALG TAVGSILLYS TVKGELHSKL
   121  ISGGHDNRVN CIQWHQDSGC LYSCSDDKHI VEWNVQTCKV KCKWKGDNSS VSSLCISPDG
   181  KMLLSAGRTI KLWVLETKEV YRHFTGHATP VSSLMFTTIR PPNESQPFDG ITGLYFLSGA
   241  VHDRLLNVWQ VRSENKEKSA VMSFTVTDEP VYIDLTLSEN KEEPVKLAVV CRDGQVHLFE
   301  HILNGYCKKP LTSNCTIQIA TPGKGKKSTP KPIPILAAGF CSDKMSLLLV YGSWFQPTIE
   361  RVALNSREPH MCLVRDISNC WAPKVETAIT KVRTPVMNSE AKVLVPGIPG HHAAIKPAPP
   421  QTEQVESKRK SGGNEVSIEE RLGAMDIDTH KKGKEDLQTN SFPVLLTQGL ESNDFEMLNK
   481  VLQTRNVNLI KKTVLRMPLH TIIPLLQELT KRLQGHPNSA VLMVQWLKCV LTVHASYLST
   541  LPDLVPQLGT LYQLMESRVK TFQKLSHLHG KLILLITQVT ASEKTKGATS PGQKAKLVYE
   601  EESSEEESDD EIADKDSEDN WDEDEEESES EKDEDVEEED EDAEGKDEEN GEDRDTASEK
   661  ELNGDSDLDP ENESEEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 52 nTPM
  • bone marrow: 40 nTPM
  • tonsil: 23 nTPM
  • urinary bladder: 23 nTPM
  • breast: 22 nTPM
  • liver: 22 nTPM

Single-cell type

  • basal keratinocytes: 296 nCPM
  • suprabasal keratinocytes: 232 nCPM
  • late spermatids: 207 nCPM
  • erythrocyte progenitors: 204 nCPM
  • ocular epithelial cells: 198 nCPM
  • megakaryocyte-erythroid progenitors: 183 nCPM

Immune cell

  • MAIT T-cell: 23 nTPM
  • NK-cell: 22 nTPM
  • naive CD4 T-cell: 20 nTPM
  • memory B-cell: 17 nTPM
  • naive B-cell: 17 nTPM
  • memory CD4 T-cell: 16 nTPM

Brain region

  • cerebellum: 33 nTPM
  • white matter: 31 nTPM
  • choroid plexus: 28 nTPM
  • hypothalamus: 28 nTPM
  • medulla oblongata: 28 nTPM
  • spinal cord: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
0.7
DepMap mean gene effect
-2.12
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR43 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR43 as an antibody target. Whether an autoantibody or antibody against WDR43 could matter depends on whether native WDR43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR43. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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