Seroatlas · Human Serome Atlas

SSX2IP

Afadin- and alpha-actinin-binding protein

Also known as: ADIP_HUMAN, hMsd1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2D8
Gene
SSX2IP
Ensembl
ENSG00000117155
Chromosome
1
Canonical length
614 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centriolar satellite,Centrosome,Basal body,Acrosome,Equatorial segment,Principal piece

OverviewNCBI Gene

This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

614 residues, UniProt reviewed canonical sequence.

>Q9Y2D8|SSX2IP
     1  MGDWMTVTDP GLSSESKTIS QYTSETKMSP SSLYSQQVLC SSIPLSKNVH SFFSAFCTED
    61  NIEQSISYLD QELTTFGFPS LYEESKGKET KRELNIVAVL NCMNELLVLQ RKNLLAQENV
   121  ETQNLKLGSD MDHLQSCYSK LKEQLETSRR EMIGLQERDR QLQCKNRNLH QLLKNEKDEV
   181  QKLQNIIASR ATQYNHDMKR KEREYNKLKE RLHQLVMNKK DKKIAMDILN YVGRADGKRG
   241  SWRTGKTEAR NEDEMYKILL NDYEYRQKQI LMENAELKKV LQQMKKEMIS LLSPQKKKPR
   301  ERVDDSTGTV ISDVEEDAGE LSRESMWDLS CETVREQLTN SIRKQWRILK SHVEKLDNQV
   361  SKVHLEGFND EDVISRQDHE QETEKLELEI QQCKEMIKTQ QQLLQQQLAT AYDDDTTSLL
   421  RDCYLLEEKE RLKEEWSLFK EQKKNFERER RSFTEAAIRL GLERKAFEEE RASWLKQQFL
   481  NMTTFDHQNS ENVKLFSAFS GSSDWDNLIV HSRQPQKKPH SVSNGSPVCM SKLTKSLPAS
   541  PSTSDFCQTR SCISEHSSIN VLNITAEEIK PNQVGGECTN QKWSVASRPG SQEGCYSGCS
   601  LSYTNSHVEK DDLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSX2IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • retina: 110 nTPM
  • testis: 99 nTPM
  • duodenum: 41 nTPM
  • cerebral cortex: 26 nTPM
  • small intestine: 25 nTPM
  • epididymis: 21 nTPM

Single-cell type

  • late spermatids: 1,688 nCPM
  • early spermatids: 958 nCPM
  • platelets: 540 nCPM
  • cone photoreceptor cells: 346 nCPM
  • late primary spermatocytes: 306 nCPM
  • rod photoreceptor cells: 273 nCPM

Immune cell

  • gdT-cell: 8.2 nTPM
  • naive CD8 T-cell: 5.1 nTPM
  • NK-cell: 4.6 nTPM
  • MAIT T-cell: 4.5 nTPM
  • plasmacytoid DC: 4.5 nTPM
  • eosinophil: 3.9 nTPM

Brain region

  • cerebral cortex: 61 nTPM
  • cerebellum: 39 nTPM
  • basal ganglia: 38 nTPM
  • white matter: 36 nTPM
  • hippocampal formation: 36 nTPM
  • amygdala: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Afadin/alpha-actinin-binding
  • Adhesion and Centrosome-associated Protein
  • Afadin- and alpha -actinin-Binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSX2IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSX2IP as an antibody target. Whether an autoantibody or antibody against SSX2IP could matter depends on whether native SSX2IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSX2IP is annotated at the cell surface, where native SSX2IP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SSX2IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SSX2IP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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