Sprouty

Definition

Sprouty (Spry) and Spred (Sprouty related EVH1 domain) proteins have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases [[cite:PMID:15683364], [cite:PMID:12391162]]. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain [[cite:PMID:15683364], [cite:PMID:12391162], [cite:PMID:10887178], [cite:PMID:11493923]]. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential [[cite:PMID:12402043], [cite:PMID:12391162]]. It also mediates homodimer formation of these proteins [[cite:PMID:15683364], [cite:PMID:12402043]]. The SPR domain can occur in association with the WH1 domain (see [interpro:IPR000697]) (located in the N-terminal part of the proteins) in the Spred proteins.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• SPRED1
• SPRED2
• SPRED3
• SPRY1
• SPRY2
• SPRY3
• SPRY4