LCE1B
Late cornified envelope protein 1B
Also known as: LCE1B_HUMAN, LEP2, SPRL2A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T7P3
- Gene
- LCE1B
- Ensembl
- ENSG00000196734
- Chromosome
- 1
- Canonical length
- 118 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>Q5T7P3|LCE1B
1 MSCQQNQQQC QPPPKCIPKC PPKCLTPRCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGSC
61 GSSSGGCCSS GGGGCCLSHH RRRRSHCHRP QSSGCCSQPS GGSSCCGGGS GQHSGGCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LCE1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
- Highest tissue expression
- 168 nTPM
Expression across tissuesHPA
Tissue
- skin: 168 nTPM
- breast: 14 nTPM
- skeletal muscle: 1.4 nTPM
- cervix: 0.9 nTPM
- salivary gland: 0.2 nTPM
- thymus: 0.2 nTPM
Single-cell type
- esophageal basal cells: 0.3 nCPM
- epididymal basal cells: 0.2 nCPM
- basal keratinocytes: 0.1 nCPM
- esophageal suprabasal cells: 0.1 nCPM
- undifferentiated spermatogonia: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0.03
- gnomAD missense Z
- -0.57
- DepMap mean gene effect
- -0.3
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LCE1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LCE1B as an antibody target. Whether an autoantibody or antibody against LCE1B could matter depends on whether native LCE1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LCE1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LCE1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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