Seroatlas · Human Serome Atlas

METTL13

eEF1A lysine and N-terminal methyltransferase

Also known as: CGI-01, DFNM1, EEF1AKNMT, EFNMT_HUMAN, FEAT, KIAA0859

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6R0
Gene: METTL13
Ensembl: ENSG00000010165
Chromosome: 1
Canonical length: 699 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>Q8N6R0|METTL13
     1  MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
    61  ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
   121  KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
   181  VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
   241  RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
   301  AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
   361  LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
   421  NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
   481  LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
   541  QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
   601  VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
   661  ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

epididymis: 18 nTPM
skeletal muscle: 15 nTPM
tonsil: 13 nTPM
lymph node: 13 nTPM
thymus: 12 nTPM
tongue: 12 nTPM

Single-cell type

erythrocyte progenitors: 54 nCPM
early spermatids: 44 nCPM
late primary spermatocytes: 29 nCPM
extravillous trophoblasts: 28 nCPM
epididymal principal cells: 27 nCPM
hofbauer cells: 23 nCPM

Immune cell

NK-cell: 11 nTPM
naive CD8 T-cell: 10 nTPM
MAIT T-cell: 9.6 nTPM
plasmacytoid DC: 8.9 nTPM
memory B-cell: 8.4 nTPM
gdT-cell: 8.3 nTPM

Brain region

cerebellum: 16 nTPM
medulla oblongata: 15 nTPM
thalamus: 15 nTPM
white matter: 15 nTPM
spinal cord: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

methylation

Molecular functions

protein-lysine N-methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL13 as an antibody target. Whether an autoantibody or antibody against METTL13 could matter depends on whether native METTL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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