Seroatlas · Human Serome Atlas

DNAJB11

DnaJ homolog subfamily B member 11

Also known as: DJB11_HUMAN, EDJ, ERdj3, HEDJ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBS4
Gene
DNAJB11
Ensembl
ENSG00000090520
Chromosome
3
Canonical length
358 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q9UBS4|DNAJB11
     1  MAPQNLSTFC LLLLYLIGAV IAGRDFYKIL GVPRSASIKD IKKAYRKLAL QLHPDRNPDD
    61  PQAQEKFQDL GAAYEVLSDS EKRKQYDTYG EEGLKDGHQS SHGDIFSHFF GDFGFMFGGT
   121  PRQQDRNIPR GSDIIVDLEV TLEEVYAGNF VEVVRNKPVA RQAPGKRKCN CRQEMRTTQL
   181  GPGRFQMTQE VVCDECPNVK LVNEERTLEV EIEPGVRDGM EYPFIGEGEP HVDGEPGDLR
   241  FRIKVVKHPI FERRGDDLYT NVTISLVESL VGFEMDITHL DGHKVHISRD KITRPGAKLW
   301  KKGEGLPNFD NNNIKGSLII TFDVDFPKEQ LTEEAREGIK QLLKQGSVQK VYNGLQGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJB11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • liver: 64 nTPM
  • pancreas: 57 nTPM
  • thyroid gland: 50 nTPM
  • appendix: 49 nTPM
  • bone marrow: 47 nTPM
  • placenta: 44 nTPM

Single-cell type

  • epididymal principal cells: 191 nCPM
  • plasma cells: 98 nCPM
  • epididymal efferent duct ciliated cells: 71 nCPM
  • megakaryocyte-erythroid progenitors: 70 nCPM
  • epididymal basal cells: 66 nCPM
  • endometrial glandular cells: 65 nCPM

Immune cell

  • plasmacytoid DC: 85 nTPM
  • NK-cell: 50 nTPM
  • myeloid DC: 46 nTPM
  • intermediate monocyte: 46 nTPM
  • gdT-cell: 44 nTPM
  • eosinophil: 40 nTPM

Brain region

  • medulla oblongata: 24 nTPM
  • white matter: 24 nTPM
  • choroid plexus: 24 nTPM
  • thalamus: 22 nTPM
  • hypothalamus: 22 nTPM
  • pons: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAJB11.

Disease | AllUniProt

Conditions DNAJB11 is implicated in, by any mechanism.

  • Polycystic kidney disease 6 with or without polycystic liver disease (PKD6) MIM:618061

Disease | GeneticClinVar

28 pathogenic / likely-pathogenic of 199 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.23
gnomAD missense Z
1.77
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJB11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJB11 as an antibody target. Whether an autoantibody or antibody against DNAJB11 could matter depends on whether native DNAJB11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJB11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJB11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAJB11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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