Seroatlas · Human Serome Atlas

CUEDC1

CUE domain-containing protein 1

Also known as: CUED1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWM3
Gene: CUEDC1
Ensembl: ENSG00000180891
Chromosome: 17
Canonical length: 386 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q9NWM3|CUEDC1
     1  MTSLFRRSSS GSGGGGTAGA RGGGGGTAAP QELNNSRPAR QVRRLEFNQA MDDFKTMFPN
    61  MDYDIIECVL RANSGAVDAT IDQLLQMNLE GGGSSGGVYE DSSDSEDSIP PEILERTLEP
   121  DSSDEEPPPV YSPPAYHMHV FDRPYPLAPP TPPPRIDALG SGAPTSQRRY RNWNPPLLGN
   181  LPDDFLRILP QQLDSIQGNA GGPKPGSGEG CPPAMAGPGP GDQESRWKQY LEDERIALFL
   241  QNEEFMKELQ RNRDFLLALE RDRLKYESQK SKSSSVAVGN DFGFSSPVPG TGDANPAVSE
   301  DALFRDKLKH MGKSTRRKLF ELARAFSEKT KMRKSKRKHL LKHQSLGAAA STANLLDDVE
   361  GHACDEDFRG RRQEAPKVEE GLREGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CUEDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 81 nTPM
colon: 38 nTPM
tongue: 37 nTPM
heart muscle: 36 nTPM
spinal cord: 33 nTPM
fallopian tube: 31 nTPM

Single-cell type

rod photoreceptor cells: 263 nCPM
cone photoreceptor cells: 224 nCPM
choroid plexus epithelial cells: 205 nCPM
oligodendrocytes: 184 nCPM
myonuclei: 163 nCPM
respiratory ciliated cells: 137 nCPM

Immune cell

plasmacytoid DC: 22 nTPM
eosinophil: 2.5 nTPM
neutrophil: 2 nTPM
non-classical monocyte: 1.9 nTPM
intermediate monocyte: 0.9 nTPM
basophil: 0.7 nTPM

Brain region

white matter: 66 nTPM
medulla oblongata: 60 nTPM
basal ganglia: 58 nTPM
thalamus: 56 nTPM
midbrain: 55 nTPM
cerebral cortex: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

ubiquitin binding

Protein domainsUniProt · Pfam · InterPro

Ubiquitin system component CUE
UBA-like superfamily
CUE domain
CUE domain-containing protein 1
CUE domain-containing protein 1, CUE domain

InteractionsUniProt · HPA

Protein binding partners of CUEDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CUEDC1 as an antibody target. Whether an autoantibody or antibody against CUEDC1 could matter depends on whether native CUEDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CUEDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CUEDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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