TM4SF5

Protein identityUniProt · HPA

UniProt accession

O14894

Gene

TM4SF5

Ensembl

ENSG00000142484

Chromosome

17

Canonical length

197 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>O14894|TM4SF5
     1  MCTGKCARCV GLSLITLCLV CIVANALLLV PNGETSWTNT NHLSLQVWLM GGFIGGGLMV
    61  LCPGIAAVRA GGKGCCGAGC CGNRCRMLRS VFSSAFGVLG AIYCLSVSGA GLRNGPRCLM
   121  NGEWGYHFED TAGAYLLNRT LWDRCEAPPR VVPWNVTLFS LLVAASCLEI VLCGIQLVNA
   181  TIGVFCGDCR KKQDTPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM4SF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

190 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.97

gnomAD pLI

0.01

gnomAD missense Z

0.79

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of G1/S transition of mitotic cell cycle

Molecular functions

• arginine binding

Cellular components

• lysosomal membrane
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• L6 membrane
• L6 membrane protein

KeywordsUniProt

• Cell cycle
• Cell membrane
• Glycoprotein
• Lysosome
• Membrane
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TM4SF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CASTOR1
• MTOR
• SLC38A9
• SLC7A1