RTKN

Protein identityUniProt · HPA

UniProt accession

Q9BST9

Gene

RTKN

Ensembl

ENSG00000114993

Chromosome

2

Canonical length

563 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q9BST9|RTKN
     1  MFSRNHRSRV TVARGSALEM EFKRGRFRLS LFSDLPEDTE LQRKLDHEIR MREGACKLLA
    61  ACSQREQALE ATKSLLVCNS RILSYMGELQ RRKEAQVLGK TSRRPSDSGP PAERSPCRGR
   121  VCISDLRIPL MWKDTEYFKN KGDLHRWAVF LLLQLGEHIQ DTEMILVDRT LTDISFQSNV
   181  LFAEAGPDFE LRLELYGACV EEEGALTGGP KRLATKLSSS LGRSSGRRVR ASLDSAGGSG
   241  SSPILLPTPV VGGPRYHLLA HTTLTLAAVQ DGFRTHDLTL ASHEENPAWL PLYGSVCCRL
   301  AAQPLCMTQP TASGTLRVQQ AGEMQNWAQV HGVLKGTNLF CYRQPEDADT GEEPLLTIAV
   361  NKETRVRAGE LDQALGRPFT LSISNQYGDD EVTHTLQTES REALQSWMEA LWQLFFDMSQ
   421  WKQCCDEIMK IETPAPRKPP QALAKQGSLY HEMAIEPLDD IAAVTDILTQ REGARLETPP
   481  PWLAMFTDQP ALPNPCSPAS VAPAPDWTHP LPWGRPRTFS LDAVPPDHSP RARSVAPLPP
   541  QRSPRTRGLC SKGQPRTWLQ SPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTKN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

121 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.76

gnomAD pLI

0

gnomAD missense Z

1.02

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actomyosin contractile ring assembly
• apoptotic process
• mitotic cytokinesis
• regulation of apoptotic process
• Rho protein signal transduction
• septin ring organization
• signal transduction

Molecular functions

• GTP binding
• GTPase inhibitor activity
• small GTPase binding

Cellular components

• actomyosin contractile ring
• cytosol

Protein domainsUniProt · Pfam · InterPro

• Pleckstrin homology domain
• HR1 rho-binding domain
• PH-like domain superfamily
• Anillin homology domain
• Cytokinesis and Rho signaling-related protein
• PH domain
• Cell division protein anillin

KeywordsUniProt

• Apoptosis
• Coiled coil
• GTP-binding
• Methylation
• Nucleotide-binding
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of RTKN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SEPT9
• RHOC
• RHOB
• RHOA
• SEPTIN9
• LIN7B