Seroatlas · Human Serome Atlas

ARHGAP1

Rho GTPase-activating protein 1

Also known as: CDC42GAP, p50rhoGAP, RHG01_HUMAN, RhoGAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q07960
Gene
ARHGAP1
Ensembl
ENSG00000175220
Chromosome
11
Canonical length
439 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q07960|ARHGAP1
     1  MDPLSELQDD LTLDDTSEAL NQLKLASIDE KNWPSDEMPD FPKSDDSKSS SPELVTHLKW
    61  DDPYYDIARH QIVEVAGDDK YGRKIIVFSA CRMPPSHQLD HSKLLGYLKH TLDQYVESDY
   121  TLLYLHHGLT SDNKPSLSWL RDAYREFDRK YKKNIKALYI VHPTMFIKTL LILFKPLISF
   181  KFGQKIFYVN YLSELSEHVK LEQLGIPRQV LKYDDFLKST QKSPATAPKP MPPRPPLPNQ
   241  QFGVSLQHLQ EKNPEQEPIP IVLRETVAYL QAHALTTEGI FRRSANTQVV REVQQKYNMG
   301  LPVDFDQYNE LHLPAVILKT FLRELPEPLL TFDLYPHVVG FLNIDESQRV PATLQVLQTL
   361  PEENYQVLRF LTAFLVQISA HSDQNKMTNT NLAVVFGPNL LWAKDAAITL KAINPINTFT
   421  KFLLDHQGEL FPSPDPSGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
119 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 119 nTPM
  • urinary bladder: 106 nTPM
  • heart muscle: 105 nTPM
  • endometrium: 82 nTPM
  • adipose tissue: 80 nTPM
  • smooth muscle: 75 nTPM

Single-cell type

  • oligodendrocytes: 147 nCPM
  • esophageal apical cells: 124 nCPM
  • retinal pigment epithelial cells: 111 nCPM
  • pericytes: 84 nCPM
  • choroid plexus epithelial cells: 83 nCPM
  • esophageal suprabasal cells: 82 nCPM

Immune cell

  • non-classical monocyte: 72 nTPM
  • intermediate monocyte: 57 nTPM
  • neutrophil: 37 nTPM
  • plasmacytoid DC: 34 nTPM
  • eosinophil: 33 nTPM
  • classical monocyte: 33 nTPM

Brain region

  • white matter: 102 nTPM
  • cerebral cortex: 89 nTPM
  • thalamus: 87 nTPM
  • basal ganglia: 84 nTPM
  • medulla oblongata: 81 nTPM
  • midbrain: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.77
gnomAD missense Z
1.25
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP1 as an antibody target. Whether an autoantibody or antibody against ARHGAP1 could matter depends on whether native ARHGAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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