Seroatlas · Human Serome Atlas

NDRG4

Protein NDRG4

Also known as: KIAA1180, NDRG4_HUMAN, SMAP-8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULP0
Gene
NDRG4
Ensembl
ENSG00000103034
Chromosome
16
Canonical length
352 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q9ULP0|NDRG4
     1  MPECWDGEHD IETPYGLLHV VIRGSPKGNR PAILTYHDVG LNHKLCFNTF FNFEDMQEIT
    61  KHFVVCHVDA PGQQVGASQF PQGYQFPSME QLAAMLPSVV QHFGFKYVIG IGVGAGAYVL
   121  AKFALIFPDL VEGLVLVNID PNGKGWIDWA ATKLSGLTST LPDTVLSHLF SQEELVNNTE
   181  LVQSYRQQIG NVVNQANLQL FWNMYNSRRD LDINRPGTVP NAKTLRCPVM LVVGDNAPAE
   241  DGVVECNSKL DPTTTTFLKM ADSGGLPQVT QPGKLTEAFK YFLQGMGYIA YLKDRRLSGG
   301  AVPSASMTRL ARSRTASLTS ASSVDGSRPQ ACTHSESSEG LGQVNHTMEV SC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDRG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
347 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 347 nTPM
  • heart muscle: 327 nTPM
  • cerebral cortex: 272 nTPM
  • basal ganglia: 242 nTPM
  • hypothalamus: 159 nTPM
  • hippocampal formation: 153 nTPM

Single-cell type

  • retinal horizontal cells: 455 nCPM
  • adrenal medulla cells: 266 nCPM
  • cardiomyocytes: 264 nCPM
  • bergmann glia: 255 nCPM
  • sertoli cells: 196 nCPM
  • retinal ganglion cells: 182 nCPM

Immune cell

  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • pons: 972 nTPM
  • cerebral cortex: 685 nTPM
  • cerebellum: 678 nTPM
  • hippocampal formation: 588 nTPM
  • thalamus: 585 nTPM
  • medulla oblongata: 577 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.01
gnomAD missense Z
0.57
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDRG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDRG4 as an antibody target. Whether an autoantibody or antibody against NDRG4 could matter depends on whether native NDRG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDRG4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDRG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDRG4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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