ITGA1

Protein identityUniProt · HPA

UniProt accession

P56199

Gene

ITGA1

Ensembl

ENSG00000213949

Chromosome

5

Canonical length

1179 aa

Protein class

Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins, Transporters

Subcellular location

Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1179 residues, UniProt reviewed canonical sequence.

>P56199|ITGA1
     1  MAPRPRARPG VAVACCWLLT VVLRCCVSFN VDVKNSMTFS GPVEDMFGYT VQQYENEEGK
    61  WVLIGSPLVG QPKNRTGDVY KCPVGRGESL PCVKLDLPVN TSIPNVTEVK ENMTFGSTLV
   121  TNPNGGFLAC GPLYAYRCGH LHYTTGICSD VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS
   181  NSIYPWDSVT AFLNDLLERM DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI
   241  VQRGGRQTMT ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE
   301  NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT IVKTLGERIF
   361  ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD WNGTVVMQKA SQIIIPRNTT
   421  FNVESTKKNE PLASYLGYTV NSATASSGDV LYIAGQPRYN HTGQVIIYRM EDGNIKILQT
   481  LSGEQIGSYF GSILTTTDID KDSNTDILLV GAPMYMGTEK EEQGKVYVYA LNQTRFEYQM
   541  SLEPIKQTCC SSRQHNSCTT ENKNEPCGAR FGTAIAAVKD LNLDGFNDIV IGAPLEDDHG
   601  GAVYIYHGSG KTIRKEYAQR IPSGGDGKTL KFFGQSIHGE MDLNGDGLTD VTIGGLGGAA
   661  LFWSRDVAVV KVTMNFEPNK VNIQKKNCHM EGKETVCINA TVCFDVKLKS KEDTIYEADL
   721  QYRVTLDSLR QISRSFFSGT QERKVQRNIT VRKSECTKHS FYMLDKHDFQ DSVRITLDFN
   781  LTDPENGPVL DDSLPNSVHE YIPFAKDCGN KEKCISDLSL HVATTEKDLL IVRSQNDKFN
   841  VSLTVKNTKD SAYNTRTIVH YSPNLVFSGI EAIQKDSCES NHNITCKVGY PFLRRGEMVT
   901  FKILFQFNTS YLMENVTIYL SATSDSEEPP ETLSDNVVNI SIPVKYEVGL QFYSSASEYH
   961  ISIAANETVP EVINSTEDIG NEINIFYLIR KSGSFPMPEL KLSISFPNMT SNGYPVLYPT
  1021  GLSSSENANC RPHIFEDPFS INSGKKMTTS TDHLKRGTIL DCNTCKFATI TCNLTSSDIS
  1081  QVNVSLILWK PTFIKSYFSS LNLTIRGELR SENASLVLSS SNQKRELAIQ ISKDGLPGRV
  1141  PLWVILLSAF AGLLLLMLLI LALWKIGFFK RPLKKKMEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

22 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.74

gnomAD pLI

0

gnomAD missense Z

0.98

DepMap mean gene effect

-0.2

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell adhesion
• cell-matrix adhesion
• cellular extravasation
• integrin-mediated signaling pathway
• negative regulation of cell population proliferation
• negative regulation of epidermal growth factor receptor signaling pathway
• neuron projection morphogenesis
• neutrophil chemotaxis
• positive regulation of MAPK cascade
• positive regulation of neuron apoptotic process
• vasodilation

Molecular functions

• collagen binding
• collagen binding involved in cell-matrix adhesion
• metal ion binding
• phosphatase activator activity
• protein phosphatase binding
• signaling receptor activity
• signaling receptor binding

Cellular components

• acrosomal vesicle
• basal part of cell
• cell surface
• external side of plasma membrane
• extracellular exosome
• focal adhesion
• integrin alpha1-beta1 complex
• integrin complex
• membrane
• perikaryon
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Integrin alpha chain
• von Willebrand factor, type A
• FG-GAP repeat
• Integrin alpha beta-propellor
• Integrin alpha, first immunoglubulin-like domain
• Integrin alpha chain, C-terminal cytoplasmic region, conserved site
• Integrin alpha, N-terminal
• Integrin domain superfamily
• von Willebrand factor A-like domain superfamily
• Integrin alpha, second immunoglobulin-like domain
• Integrin alpha, third immunoglobulin-like domain
• von Willebrand factor type A domain
• FG-GAP repeat
• Integrin alpha Ig-like domain 1
• Integrin alpha Ig-like domain 2
• Integrin alpha Ig-like domain 3

KeywordsUniProt

• Calcium
• Cell adhesion
• Disulfide bond
• Glycoprotein
• Integrin
• Magnesium
• Membrane
• Metal-binding
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ITGA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RAB21
• SEMA7A
• PTPN2
• AUP1