Seroatlas · Human Serome Atlas

ITGA11

Integrin alpha-11

Also known as: HsT18964, ITA11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKX5
Gene
ITGA11
Ensembl
ENSG00000137809
Chromosome
15
Canonical length
1188 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1188 residues, UniProt reviewed canonical sequence.

>Q9UKX5|ITGA11
     1  MDLPRGLVVA WALSLWPGFT DTFNMDTRKP RVIPGSRTAF FGYTVQQHDI SGNKWLVVGA
    61  PLETNGYQKT GDVYKCPVIH GNCTKLNLGR VTLSNVSERK DNMRLGLSLA TNPKDNSFLA
   121  CSPLWSHECG SSYYTTGMCS RVNSNFRFSK TVAPALQRCQ TYMDIVIVLD GSNSIYPWVE
   181  VQHFLINILK KFYIGPGQIQ VGVVQYGEDV VHEFHLNDYR SVKDVVEAAS HIEQRGGTET
   241  RTAFGIEFAR SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIQQSERD NVTRYAVAVL
   301  GYYNRRGINP ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDALGDRIF SLEGTNKNET
   361  SFGLEMSQTG FSSHVVEDGV LLGAVGAYDW NGAVLKETSA GKVIPLRESY LKEFPEELKN
   421  HGAYLGYTVT SVVSSRQGRV YVAGAPRFNH TGKVILFTMH NNRSLTIHQA MRGQQIGSYF
   481  GSEITSVDID GDGVTDVLLV GAPMYFNEGR ERGKVYVYEL RQNLFVYNGT LKDSHSYQNA
   541  RFGSSIASVR DLNQDSYNDV VVGAPLEDNH AGAIYIFHGF RGSILKTPKQ RITASELATG
   601  LQYFGCSIHG QLDLNEDGLI DLAVGALGNA VILWSRPVVQ INASLHFEPS KINIFHRDCK
   661  RSGRDATCLA AFLCFTPIFL APHFQTTTVG IRYNATMDER RYTPRAHLDE GGDRFTNRAV
   721  LLSSGQELCE RINFHVLDTA DYVKPVTFSV EYSLEDPDHG PMLDDGWPTT LRVSVPFWNG
   781  CNEDEHCVPD LVLDARSDLP TAMEYCQRVL RKPAQDCSAY TLSFDTTVFI IESTRQRVAV
   841  EATLENRGEN AYSTVLNISQ SANLQFASLI QKEDSDGSIE CVNEERRLQK QVCNVSYPFF
   901  RAKAKVAFRL DFEFSKSIFL HHLEIELAAG SDSNERDSTK EDNVAPLRFH LKYEADVLFT
   961  RSSSLSHYEV KPNSSLERYD GIGPPFSCIF RIQNLGLFPI HGMMMKITIP IATRSGNRLL
  1021  KLRDFLTDEA NTSCNIWGNS TEYRPTPVEE DLRRAPQLNH SNSDVVSINC NIRLVPNQEI
  1081  NFHLLGNLWL RSLKALKYKS MKIMVNAALQ RQFHSPFIFR EEDPSRQIVF EISKQEDWQV
  1141  PIWIIVGSTL GGLLLLALLV LALWKLGFFR SARRRREPGL DPTPKVLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGA11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 74 nTPM
  • endometrium: 29 nTPM
  • smooth muscle: 23 nTPM
  • cervix: 16 nTPM
  • epididymis: 13 nTPM
  • fallopian tube: 7.9 nTPM

Single-cell type

  • fibro-adipogenic progenitors: 273 nCPM
  • retinal amacrine cells: 90 nCPM
  • hepatic stellate cells: 78 nCPM
  • epididymal principal cells: 69 nCPM
  • fibroblasts: 66 nCPM
  • peritubular myoid cells: 53 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 5.6 nTPM
  • cerebellum: 4.1 nTPM
  • white matter: 3.6 nTPM
  • choroid plexus: 3.3 nTPM
  • hypothalamus: 3.3 nTPM
  • hippocampal formation: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0
gnomAD missense Z
0.81
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITGA11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITGA11 as an antibody target. Whether an autoantibody or antibody against ITGA11 could matter depends on whether native ITGA11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITGA11 is annotated at the cell surface, where native ITGA11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITGA11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ITGA11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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