Seroatlas · Human Serome Atlas

PLSCR3

Phospholipid scramblase 3

Also known as: PLS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRY6
Gene: PLSCR3
Ensembl: ENSG00000187838
Chromosome: 17
Canonical length: 295 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Mitochondria
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in several processes, including apoptotic process; mitochondrial membrane organization; and regulation of release of cytochrome c from mitochondria. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>Q9NRY6|PLSCR3
     1  MAGYLPPKGY APSPPPPYPV TPGYPEPALH PGPGQAPVPA QVPAPAPGFA LFPSPGPVAL
    61  GSAAPFLPLP GVPSGLEFLV QIDQILIHQK AERVETFLGW ETCNRYELRS GAGQPLGQAA
   121  EESNCCARLC CGARRPLRVR LADPGDREVL RLLRPLHCGC SCCPCGLQEM EVQAPPGTTI
   181  GHVLQTWHPF LPKFSIQDAD RQTVLRVVGP CWTCGCGTDT NFEVKTRDES RSVGRISKQW
   241  GGLVREALTD ADDFGLQFPL DLDVRVKAVL LGATFLIDYM FFEKRGGAGP SAVTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLSCR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 47 nTPM
cervix: 42 nTPM
endometrium: 42 nTPM
spleen: 40 nTPM
esophagus: 37 nTPM
vagina: 37 nTPM

Single-cell type

astrocytes: 6.5 nCPM
other brain neurons: 5.8 nCPM
bergmann glia: 5.6 nCPM
brain inhibitory neurons: 5.2 nCPM
brain excitatory neurons: 4.8 nCPM
oligodendrocyte progenitor cells: 4.6 nCPM

Immune cell

T-reg: 84 nTPM
memory CD4 T-cell: 73 nTPM
naive CD4 T-cell: 59 nTPM
MAIT T-cell: 41 nTPM
memory CD8 T-cell: 41 nTPM
gdT-cell: 40 nTPM

Brain region

medulla oblongata: 9.1 nTPM
thalamus: 8.4 nTPM
pons: 7 nTPM
white matter: 7 nTPM
spinal cord: 6.8 nTPM
amygdala: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic process
cellular response to lipopolysaccharide
cholesterol homeostasis
glucose homeostasis
mitochondrial membrane organization
plasma membrane phospholipid scrambling
regulation of apoptotic process
regulation of release of cytochrome c from mitochondria

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLSCR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLSCR3 as an antibody target. Whether an autoantibody or antibody against PLSCR3 could matter depends on whether native PLSCR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLSCR3 is annotated at the cell surface, where native PLSCR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLSCR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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