FBRS
Probable fibrosin-1
Also known as: FBRS_HUMAN, FBS, FBS1, FLJ11618
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9HAH7
- Gene
- FBRS
- Ensembl
- ENSG00000156860
- Chromosome
- 16
- Canonical length
- 460 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
460 residues, UniProt reviewed canonical sequence.
>Q9HAH7|FBRS
1 MFEKYPGKME GLFRHNPYTA FPPAVPGLPP GLPPAVSFGS LQGAFQPKST NPELPPRLGP
61 VPSGLSQKGT QIPDHFRPPL RKPGKWCAMH VRVAYMILRH QEKMKGDSHK LDFRNDLLPC
121 LPGPYGALPP GQELSHPASL FTATGAVHAA ANPFTAAPGA HGPFLSPSTH IDPFGRPTSF
181 ASLAALSNGA FGGLGSPTFN SGAVFAQKES PGAPPAFASP PDPWGRLHRS PLTFPAWVRP
241 PEAARTPGSD KERPVERREP SITKEEKDRD LPFSRPQLRV SPATPKARAG EEGPRPTKES
301 VRVKEERKEE AAAAAAAAAA AAAAAAAAAT GPQGLHLLFE RPRPPPFLGP SPPDRCAGFL
361 EPTWLAAPPR LARPPRFYEA GEELTGPGAV AAARLYGLEP AHPLLYSRLA PPPPPAAAPG
421 TPHLLSKTPP GALLGAPPPL VPAPRPSSPP RGPGPARADRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FBRS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 113 nTPM
Expression across tissuesHPA
Tissue
- testis: 113 nTPM
- pituitary gland: 57 nTPM
- esophagus: 56 nTPM
- bone marrow: 53 nTPM
- skin: 51 nTPM
- spleen: 51 nTPM
Single-cell type
- late spermatids: 192 nCPM
- neutrophils: 172 nCPM
- platelets: 141 nCPM
- esophageal apical cells: 122 nCPM
- late primary spermatocytes: 105 nCPM
- early spermatids: 93 nCPM
Immune cell
- neutrophil: 2.1 nTPM
- classical monocyte: 1 nTPM
- plasmacytoid DC: 1 nTPM
- naive CD8 T-cell: 0.9 nTPM
- total PBMC: 0.9 nTPM
- eosinophil: 0.8 nTPM
Brain region
- medulla oblongata: 58 nTPM
- cerebral cortex: 56 nTPM
- amygdala: 54 nTPM
- thalamus: 54 nTPM
- hippocampal formation: 53 nTPM
- white matter: 53 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about FBRS.
Disease | GeneticClinVar
2 pathogenic / likely-pathogenic of 104 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.16
- gnomAD pLI
- 1
- gnomAD missense Z
- 0.76
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FBRS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FBRS as an antibody target. Whether an autoantibody or antibody against FBRS could matter depends on whether native FBRS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FBRS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FBRS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...