Seroatlas · Human Serome Atlas

KPNA6

Importin subunit alpha-7

Also known as: FLJ11249, IMA7_HUMAN, IPOA7, KPNA7, MGC17918

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60684
Gene: KPNA6
Ensembl: ENSG00000025800
Chromosome: 1
Canonical length: 536 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>O60684|KPNA6
     1  METMASPGKD NYRMKSYKNN ALNPEEMRRR REEEGIQLRK QKREQQLFKR RNVELINEEA
    61  AMFDSLLMDS YVSSTTGESV ITREMVEMLF SDDSDLQLAT TQKFRKLLSK EPSPPIDEVI
   121  NTPRVVDRFV EFLKRNENCT LQFEAAWALT NIASGTSQQT KIVIEAGAVP IFIELLNSDF
   181  EDVQEQAVWA LGNIAGDSSV CRDYVLNCSI LNPLLTLLTK STRLTMTRNA VWALSNLCRG
   241  KNPPPEFAKV SPCLPVLSRL LFSSDSDLLA DACWALSYLS DGPNEKIQAV IDSGVCRRLV
   301  ELLMHNDYKV ASPALRAVGN IVTGDDIQTQ VILNCSALPC LLHLLSSPKE SIRKEACWTI
   361  SNITAGNRAQ IQAVIDANIF PVLIEILQKA EFRTRKEAAW AITNATSGGT PEQIRYLVSL
   421  GCIKPLCDLL TVMDSKIVQV ALNGLENILR LGEQEGKRSG SGVNPYCGLI EEAYGLDKIE
   481  FLQSHENQEI YQKAFDLIEH YFGVEDDDSS LAPQVDETQQ QFIFQQPEAP MEGFQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KPNA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 37 nTPM
parathyroid gland: 23 nTPM
tongue: 22 nTPM
heart muscle: 21 nTPM
bone marrow: 19 nTPM
testis: 19 nTPM

Single-cell type

myonuclei: 171 nCPM
syncytiotrophoblasts: 152 nCPM
podocytes: 110 nCPM
neutrophil progenitors: 100 nCPM
renal collecting duct intercalated cells: 98 nCPM
renal connecting tubule cells: 88 nCPM

Immune cell

non-classical monocyte: 9.9 nTPM
intermediate monocyte: 9.1 nTPM
gdT-cell: 7.7 nTPM
MAIT T-cell: 7.5 nTPM
classical monocyte: 7.4 nTPM
naive CD4 T-cell: 7.4 nTPM

Brain region

pons: 55 nTPM
hypothalamus: 52 nTPM
midbrain: 51 nTPM
medulla oblongata: 49 nTPM
cerebral cortex: 46 nTPM
thalamus: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 3.34
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KPNA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KPNA6 as an antibody target. Whether an autoantibody or antibody against KPNA6 could matter depends on whether native KPNA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KPNA6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KPNA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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