SAM-dependent methyltransferase RsmB-F/NOP2-type domain

Definition

This domain is found in a group of class I-like SAM-binding methyltransferases from all cellular organisms. It includes the catalytic core of this enzimes ([interpro:IPR049560]). The catalytic domain of ribosomal RNA cysteine methyltransferases is highly conserved in archaeal, bacterial and eukaryotic proteins PMID:21123870. It is located at the C-terminal end in ribosomal RNA methyltransferase B (RsmB, Sun, Fmu) and Nop2 and towards the N-terminal in RsmF. Escherichia coli RsmB methylates cytosine C967 in 16S rRNA PMID:21123870. RsmF is a multi-site-specific methyltransferase PMID:20558545. Nop2 methylates cytosine C2870 in the 25S rRNA of S. cerevisiae PMID:23913415 and is critical for 60S biogenesis PMID:8972218.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• NOP2
• NSUN2
• NSUN3
• NSUN4
• NSUN5
• NSUN5P1
• NSUN5P2
• NSUN6
• NSUN7