Seroatlas · Human Serome Atlas

WDR46

WD repeat-containing protein 46

Also known as: BING4, C6orf11, UTP7, WDR46_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15213
Gene: WDR46
Ensembl: ENSG00000227057
Chromosome: 6
Canonical length: 610 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in nucleolus. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>O15213|WDR46
     1  METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN RELRPQRPKN
    61  AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG PAPVPVEVVQ KFCRIDKSRK
   121  LPHSKAKTRS RLEVAEAEEE ETSIKAARSE LLLAEEPGFL EGEDGEDTAK ICQADIVEAV
   181  DIASAAKHFD LNLRQFGPYR LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR
   241  DIRFLHSEAL LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT
   301  YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE PLAKILCHRG
   361  GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL PHGAGHLAFS QRGLLVAGMG
   421  DVVNIWAGQG KASPPSLEQP YLTHRLSGPV HGLQFCPFED VLGVGHTGGI TSMLVPGAGE
   481  PNFDGLESNP YRSRKQRQEW EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL
   541  GYDPQAKAPF QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA
   601  RPSALDRFVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 29 nTPM
skin: 27 nTPM
endometrium: 27 nTPM
cervix: 25 nTPM
blood vessel: 24 nTPM
spleen: 24 nTPM

Single-cell type

early spermatids: 72 nCPM
oocytes: 51 nCPM
late primary spermatocytes: 44 nCPM
decidual stromal cells: 42 nCPM
differentiating spermatogonia: 40 nCPM
hepatic stellate cells: 39 nCPM

Immune cell

non-classical monocyte: 34 nTPM
intermediate monocyte: 29 nTPM
NK-cell: 28 nTPM
myeloid DC: 28 nTPM
gdT-cell: 25 nTPM
memory CD8 T-cell: 22 nTPM

Brain region

white matter: 5.7 nTPM
cerebral cortex: 5.6 nTPM
hippocampal formation: 3.9 nTPM
hypothalamus: 3.9 nTPM
pons: 3.8 nTPM
medulla oblongata: 3.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR46.

Disease | ImmuneIEDB

Conditions an epitope on WDR46 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.86
DepMap mean gene effect: -1.06
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
BING4, C-terminal domain
WD repeat-containing protein WDR46/Utp7
BING4CT (NUC141) domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR46 as an antibody target. Whether an autoantibody or antibody against WDR46 could matter depends on whether native WDR46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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