Seroatlas · Human Serome Atlas

UBXN7

UBX domain-containing protein 7

Also known as: KIAA0794, UBXD7, UBXN7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94888
Gene: UBXN7
Ensembl: ENSG00000163960
Chromosome: 3
Canonical length: 489 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

489 residues, UniProt reviewed canonical sequence.

>O94888|UBXN7
     1  MAAHGGSAAS SALKGLIQQF TTITGASESV GKHMLEACNN NLEMAVTMFL DGGGIAEEPS
    61  TSSASVSTVR PHTEEEVRAP IPQKQEILVE PEPLFGAPKR RRPARSIFDG FRDFQTETIR
   121  QEQELRNGGA IDKKLTTLAD LFRPPIDLMH KGSFETAKEC GQMQNKWLMI NIQNVQDFAC
   181  QCLNRDVWSN EAVKNIIREH FIFWQVYHDS EEGQRYIQFY KLGDFPYVSI LDPRTGQKLV
   241  EWHQLDVSSF LDQVTGFLGE HGQLDGLSSS PPKKCARSES LIDASEDSQL EAAIRASLQE
   301  THFDSTQTKQ DSRSDEESES ELFSGSEEFI SVCGSDEEEE VENLAKSRKS PHKDLGHRKE
   361  ENRRPLTEPP VRTDPGTATN HQGLPAVDSE ILEMPPEKAD GVVEGIDVNG PKAQLMLRYP
   421  DGKREQITLP EQAKLLALVK HVQSKGYPNE RFELLTNFPR RKLSHLDYDI TLQEAGLCPQ
   481  ETVFVQERN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 21 nTPM
retina: 17 nTPM
thymus: 13 nTPM
testis: 11 nTPM
parathyroid gland: 10 nTPM
skin: 10 nTPM

Single-cell type

neutrophils: 197 nCPM
neutrophil progenitors: 144 nCPM
myonuclei: 111 nCPM
thyrotrophs: 109 nCPM
sertoli cells: 104 nCPM
lactotrophs: 102 nCPM

Immune cell

basophil: 10 nTPM
neutrophil: 8.4 nTPM
eosinophil: 7 nTPM
memory B-cell: 7 nTPM
T-reg: 6.6 nTPM
naive CD4 T-cell: 6.5 nTPM

Brain region

cerebellum: 59 nTPM
white matter: 44 nTPM
hypothalamus: 42 nTPM
midbrain: 39 nTPM
choroid plexus: 38 nTPM
basal ganglia: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 3.18
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome-mediated ubiquitin-dependent protein catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN7 as an antibody target. Whether an autoantibody or antibody against UBXN7 could matter depends on whether native UBXN7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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