Seroatlas · Human Serome Atlas

KHNYN

Protein KHNYN

Also known as: KHNYN_HUMAN, KIAA0323

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15037
Gene: KHNYN
Ensembl: ENSG00000100441
Chromosome: 14
Canonical length: 678 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a ribonuclease NYN domain and belongs to the N4BP1 family. The protein is a cofactor for the zinc finger antiviral protein (ZAP protein) which targets viral RNA for degradation and restricts SARS-CoV-2 infection. [provided by RefSeq, Sep 2021]

Canonical amino-acid sequenceUniProt

678 residues, UniProt reviewed canonical sequence.

>O15037|KHNYN
     1  MPTWGARPAS PDRFAVSAEA ENKVREQQPH VERIFSVGVS VLPKDCPDNP HIWLQLEGPK
    61  ENASRAKEYL KGLCSPELQD EIHYPPKLHC IFLGAQGFFL DCLAWSTSAH LVPRAPGSLM
   121  ISGLTEAFVM AQSRVEELAE RLSWDFTPGP SSGASQCTGV LRDFSALLQS PGDAHREALL
   181  QLPLAVQEEL LSLVQEASSG QGPGALASWE GRSSALLGAQ CQGVRAPPSD GRESLDTGSM
   241  GPGDCRGARG DTYAVEKEGG KQGGPREMDW GWKELPGEEA WEREVALRPQ SVGGGARESA
   301  PLKGKALGKE EIALGGGGFC VHREPPGAHG SCHRAAQSRG ASLLQRLHNG NASPPRVPSP
   361  PPAPEPPWHC GDRGDCGDRG DVGDRGDKQQ GMARGRGPQW KRGARGGNLV TGTQRFKEAL
   421  QDPFTLCLAN VPGQPDLRHI VIDGSNVAMV HGLQHYFSSR GIAIAVQYFW DRGHRDITVF
   481  VPQWRFSKDA KVRESHFLQK LYSLSLLSLT PSRVMDGKRI SSYDDRFMVK LAEETDGIIV
   541  SNDQFRDLAE ESEKWMAIIR ERLLPFTFVG NLFMVPDDPL GRNGPTLDEF LKKPARTQGS
   601  SKAQHPSRGF AEHGKQQQGR EEEKGSGGIR KTRETERLRR QLLEVFWGQD HKVDFILQRE
   661  PYCRDINQLS EALLSLNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KHNYN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

ovary: 38 nTPM
bone marrow: 37 nTPM
stomach: 37 nTPM
small intestine: 32 nTPM
placenta: 31 nTPM
spleen: 30 nTPM

Single-cell type

cardiomyocytes: 123 nCPM
epicardial cells: 89 nCPM
foveolar cells: 52 nCPM
tuft cells: 46 nCPM
esophageal apical cells: 41 nCPM
pancreatic acinar cells: 40 nCPM

Immune cell

naive B-cell: 2.3 nTPM
eosinophil: 1.9 nTPM
gdT-cell: 1.7 nTPM
neutrophil: 1.7 nTPM
intermediate monocyte: 1.6 nTPM
NK-cell: 1.6 nTPM

Brain region

cerebellum: 36 nTPM
medulla oblongata: 35 nTPM
white matter: 33 nTPM
basal ganglia: 28 nTPM
pons: 27 nTPM
cerebral cortex: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of KHNYN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NEDD8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KHNYN as an antibody target. Whether an autoantibody or antibody against KHNYN could matter depends on whether native KHNYN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KHNYN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KHNYN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...