Seroatlas · Human Serome Atlas

SUN1

SUN domain-containing protein 1

Also known as: FLJ12407, KIAA0810, SUN1_HUMAN, UNC84A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94901
Gene: SUN1
Ensembl: ENSG00000164828
Chromosome: 7
Canonical length: 785 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nuclear membrane

OverviewNCBI Gene

This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]

Canonical amino-acid sequenceUniProt

785 residues, UniProt reviewed canonical sequence.

>O94901|SUN1
     1  MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT
    61  TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ VTSSGVSHGG
   121  TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG DVGAAAATAH
   181  NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKC YFLLQILRRI GAVGQAVSRT
   241  AWSALWLAVV APGKAASGVF WWLGIGWYQF VTLISWLNVF LLTRCLRNIC KFLVLLIPLF
   301  LLLAGLSLRG QGNFFSFLPV LNWASMHRTQ RVDDPQDVFK PTTSRLKQPL QGDSEAFPWH
   361  WMSGVEQQVA SLSGQCHHHG ENLRELTTLL QKLQARVDQM EGGAAGPSAS VRDAVGQPPR
   421  ETDFMAFHQE HEVRMSHLED ILGKLREKSE AIQKELEQTK QKTISAVGEQ LLPTVEHLQL
   481  ELDQLKSELS SWRHVKTGCE TVDAVQERVD VQVREMVKLL FSEDQQGGSL EQLLQRFSSQ
   541  FVSKGDLQTM LRDLQLQILR NVTHHVSVTK QLPTSEAVVS AVSEAGASGI TEAQARAIVN
   601  SALKLYSQDK TGMVDFALES GGGSILSTRC SETYETKTAL MSLFGIPLWY FSQSPRVVIQ
   661  PDIYPGNCWA FKGSQGYLVV RLSMMIHPAA FTLEHIPKTL SPTGNISSAP KDFAVYGLEN
   721  EYQEEGQLLG QFTYDQDGES LQMFQALKRP DDTAFQIVEL RIFSNWGHPE YTCLYRFRVH
   781  GEPVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 112 nTPM
cerebellum: 97 nTPM
tongue: 93 nTPM
skin: 82 nTPM
ovary: 81 nTPM
cervix: 73 nTPM

Single-cell type

late spermatids: 847 nCPM
early spermatids: 470 nCPM
endometrial ciliated cells: 304 nCPM
endometrial glandular cells: 285 nCPM
corticotrophs: 246 nCPM
endometrial luminal cells: 241 nCPM

Immune cell

basophil: 12 nTPM
naive CD4 T-cell: 11 nTPM
classical monocyte: 9.4 nTPM
intermediate monocyte: 8.3 nTPM
memory CD4 T-cell: 7.9 nTPM
myeloid DC: 7.6 nTPM

Brain region

cerebellum: 82 nTPM
cerebral cortex: 56 nTPM
choroid plexus: 53 nTPM
midbrain: 50 nTPM
basal ganglia: 46 nTPM
hippocampal formation: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SUN domain
SUN coiled coil domain 2
SUN domain-containing protein 1-5
Sad1 / UNC-like C-terminal
SUN2 helix-turn-helix domain
SUN domain-containing protein 1, N-terminal
Mitochondrial RNA binding protein MRP

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUN1 as an antibody target. Whether an autoantibody or antibody against SUN1 could matter depends on whether native SUN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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