Seroatlas · Human Serome Atlas

DLST

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Also known as: DLTS, KGD2, ODO2_HUMAN, OGDC-E2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36957
Gene
DLST
Ensembl
ENSG00000119689
Chromosome
14
Canonical length
453 aa
Protein class
Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>P36957|DLST
     1  MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI NNSVFSVRFF
    61  RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAED EVVCEIETDK TSVQVPSPAN
   121  GVIEALLVPD GGKVEGGTPL FTLRKTGAAP AKAKPAEAPA AAAPKAEPTA AAVPPPAAPI
   181  PTQMPPVPSP SQPPSGKPVS AVKPTVAPPL AEPGAGKGLR SEHREKMNRM RQRIAQRLKE
   241  AQNTCAMLTT FNEIDMSNIQ EMRARHKEAF LKKHNLKLGF MSAFVKASAF ALQEQPVVNA
   301  VIDDTTKEVV YRDYIDISVA VATPRGLVVP VIRNVEAMNF ADIERTITEL GEKARKNELA
   361  IEDMDGGTFT ISNGGVFGSL FGTPIINPPQ SAILGMHGIF DRPVAIGGKV EVRPMMYVAL
   421  TYDHRLIDGR EAVTFLRKIK AAVEDPRVLL LDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLST can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
209 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 209 nTPM
  • skeletal muscle: 138 nTPM
  • heart muscle: 123 nTPM
  • kidney: 94 nTPM
  • adrenal gland: 82 nTPM
  • liver: 76 nTPM

Single-cell type

  • syncytiotrophoblasts: 126 nCPM
  • platelets: 99 nCPM
  • esophageal basal cells: 93 nCPM
  • esophageal suprabasal cells: 93 nCPM
  • esophageal apical cells: 86 nCPM
  • rod photoreceptor cells: 81 nCPM

Immune cell

  • NK-cell: 3.5 nTPM
  • basophil: 3 nTPM
  • plasmacytoid DC: 2.8 nTPM
  • eosinophil: 2.3 nTPM
  • naive CD8 T-cell: 2.2 nTPM
  • gdT-cell: 2.1 nTPM

Brain region

  • choroid plexus: 55 nTPM
  • thalamus: 41 nTPM
  • cerebellum: 37 nTPM
  • medulla oblongata: 37 nTPM
  • hypothalamus: 36 nTPM
  • midbrain: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DLST.

Disease | AllUniProt

Conditions DLST is implicated in, by any mechanism.

  • Pheochromocytoma/paraganglioma syndrome 7 (PPGL7) MIM:618475

Disease | ImmuneIEDB

Conditions an epitope on DLST was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.48
gnomAD missense Z
0.58
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLST in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLST as an antibody target. Whether an autoantibody or antibody against DLST could matter depends on whether native DLST is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLST is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DLST as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLST. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...