Seroatlas · Human Serome Atlas

NAP1L4

Nucleosome assembly protein 1-like 4

Also known as: NAP2, NP1L4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99733
Gene
NAP1L4
Ensembl
ENSG00000205531
Chromosome
11
Canonical length
375 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q99733|NAP1L4
     1  MADHSFSDGV PSDSVEAAKN ASNTEKLTDQ VMQNPRVLAA LQERLDNVPH TPSSYIETLP
    61  KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ PLFDKRREFI TGDVEPTDAE
   121  SEWHSENEEE EKLAGDMKSK VVVTEKAAAT AEEPDPKGIP EFWFTIFRNV DMLSELVQEY
   181  DEPILKHLQD IKVKFSDPGQ PMSFVLEFHF EPNDYFTNSV LTKTYKMKSE PDKADPFSFE
   241  GPEIVDCDGC TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFNPLKASG
   301  DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE EGEEEELEGD
   361  EEGEDEDDAE INPKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAP1L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
139 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 139 nTPM
  • spinal cord: 129 nTPM
  • midbrain: 128 nTPM
  • heart muscle: 106 nTPM
  • tongue: 103 nTPM
  • basal ganglia: 102 nTPM

Single-cell type

  • choroid plexus epithelial cells: 379 nCPM
  • distal convoluted tubule cells: 239 nCPM
  • renal collecting duct intercalated cells: 214 nCPM
  • renal connecting tubule cells: 188 nCPM
  • oligodendrocytes: 177 nCPM
  • proximal tubule cells: 152 nCPM

Immune cell

  • T-reg: 70 nTPM
  • basophil: 68 nTPM
  • NK-cell: 57 nTPM
  • memory CD8 T-cell: 53 nTPM
  • naive CD8 T-cell: 52 nTPM
  • memory CD4 T-cell: 52 nTPM

Brain region

  • choroid plexus: 126 nTPM
  • white matter: 116 nTPM
  • thalamus: 115 nTPM
  • medulla oblongata: 112 nTPM
  • pons: 108 nTPM
  • midbrain: 105 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.77
gnomAD missense Z
0.72
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAP1L4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAP1L4 as an antibody target. Whether an autoantibody or antibody against NAP1L4 could matter depends on whether native NAP1L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAP1L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAP1L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAP1L4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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