Seroatlas · Human Serome Atlas

NAP1L5

Nucleosome assembly protein 1-like 5

Also known as: DRLM, NP1L5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NT1
Gene: NAP1L5
Ensembl: ENSG00000177432
Chromosome: 4
Canonical length: 182 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that shares sequence similarity to nucleosome assembly factors, but may be localized to the cytoplasm rather than the nucleus. Expression of this gene is downregulated in hepatocellular carcinomas. This gene is located within a differentially methylated region (DMR) and is imprinted and paternally expressed. There is a related pseudogene on chromosome 4. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q96NT1|NAP1L5
     1  MADSENQGPA EPSQAAAAAE AAAEEVMAEG GAQGGDCDSA AGDPDSAAGQ MAEEPQTPAE
    61  NAPKPKNDFI ESLPNSVKCR VLALKKLQKR CDKIEAKFDK EFQALEKKYN DIYKPLLAKI
   121  QELTGEMEGC AWTLEGEEEE EEEYEDDEEE GEDEEEEEAA AEAAAGAKHD DAHAEMPDDA
   181  KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAP1L5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 127 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 127 nTPM
cerebral cortex: 101 nTPM
midbrain: 61 nTPM
cerebellum: 61 nTPM
amygdala: 58 nTPM
hippocampal formation: 53 nTPM

Single-cell type

other brain neurons: 72 nCPM
brain inhibitory neurons: 36 nCPM
adrenal medulla cells: 32 nCPM
brain excitatory neurons: 32 nCPM
smooth muscle cells: 31 nCPM
corticotrophs: 29 nCPM

Immune cell

gdT-cell: 1.4 nTPM
naive CD4 T-cell: 1.2 nTPM
naive CD8 T-cell: 1.1 nTPM
memory CD8 T-cell: 1 nTPM
MAIT T-cell: 0.9 nTPM
T-reg: 0.7 nTPM

Brain region

hypothalamus: 158 nTPM
pons: 120 nTPM
cerebral cortex: 114 nTPM
midbrain: 106 nTPM
basal ganglia: 87 nTPM
medulla oblongata: 82 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.69
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nucleosome assembly

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAP1L5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NAP1L1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAP1L5 as an antibody target. Whether an autoantibody or antibody against NAP1L5 could matter depends on whether native NAP1L5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAP1L5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAP1L5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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